PMID: 6975975Aug 1, 1981Paper

T-cell subset analysis by monoclonal antibodies in primary immunodeficiencies

Scandinavian Journal of Immunology
F Phan-Dinh-TuyM A Bach

Abstract

T-cell subsets have been analysed in 23 cases of primary immunodeficiency with monoclonal antibodies. Functional assays investigating T-cell function--proliferative response to mitogens, antigens, and allogeneic cells, cytotoxicity generated against allogeneic target cells and helper function to pokeweek mitogen-induced immunoglobulin synthesis--were performed in parallel in the same patients. The results enabled us to delineate four groups of patients. The first group consisted of patients in whom marker and function studies show concordant data, with either normal or strongly decreased T-cell number and function. The second group consisted of patients in whom various degrees of functional abnormality coexist with subnormal T-cell number and increased suppressor T-cell proportion. In the third group, we collected all patients who showed functional deficiencies without marker abnormalities. Finally, there was a small group composed of patients whose T-cell pattern was strongly suggestive of abnormal differentiation.

References

May 10, 1979·The New England Journal of Medicine·E L ReinherzS F Schlossman
Dec 1, 1979·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Sep 1, 1975·Clinical Immunology and Immunopathology·A DurandyC Griscelli
Oct 1, 1978·The American Journal of Medicine·C GriscelliM Prunieras
Jul 1, 1976·The Journal of Clinical Investigation·F P SiegalR A Good
Nov 15, 1969·Lancet·H W Lischner, A M DiGeorge
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman
Aug 19, 1965·The New England Journal of Medicine·G S OMENN

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Citations

Apr 1, 1982·Journal of Clinical Immunology·G CarellaM A Bach
Jan 1, 1992·Annales de biologie clinique·A Ruiz-Arguelles
Mar 16, 1984·Journal of Immunological Methods·V Bongers, J Bertrams
Feb 1, 1983·Immunology Letters·F MerinoP Ramírez-Duque
May 1, 1983·Archives of Disease in Childhood·E G DaviesD C Linch
Jan 1, 1989·Journal of Clinical Laboratory Analysis·H B SladeS A Schwartz
Oct 1, 1983·The Journal of Pediatrics·S TsuchiyaK Tada

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