T cell subsets and Langerhans cells in lichen planus: in situ characterization using monoclonal antibodies

The British Journal of Dermatology
A K BhanM C Mihm

Abstract

Skin biopsies from four patients with lichen planus were studied using monoclonal antibodies directed against T lymphocytes. Anti-TI and anti-T3 antibodies, which react with all peripheral T cells, stained most cells in the dermal infiltrates. The majority of infiltrating cells also stained with anti-T4 and anti-T4b antibodies, which react with helper/inducer cells, whereas a minority of cells stained with anti-T8 antibody, which reacts with cytotoxic/suppressor cells. Surface IgM was not identified on any infiltrating cells, providing evidence against B cell participation. Intraepidermal and dermal cells with long cytoplasmic extensions stained with any anti-T6 antibody in all cases, defining them as Langerhans cells or their precursors. T6-positive cells were seen in greater number than in normal control epidermis and dermis. The results indicate that well-developed lesions of lichen planus are characterized by an influx of helper/inducer T lymphocytes and increased numbers of Langerhans cells. These observations support the contention that cellular immunity is important in the pathogenesis of this disorder.

References

Jul 1, 1979·Oral Surgery, Oral Medicine, and Oral Pathology·H M Dockrell, J S Greenspan
Dec 1, 1979·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Jun 1, 1978·The British Journal of Dermatology·J R Bjerke, H K Krogh
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Nov 1, 1979·The Journal of Investigative Dermatology·P Holmstrup, E Dabelsteen
Sep 1, 1974·The British Journal of Dermatology·D Weedon
Oct 1, 1980·The Journal of Experimental Medicine·A K BhanS F Schlossman
Jan 1, 1981·The Journal of Experimental Medicine·S PoppemaS F Schlossman
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E FithianR Edelson
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman
Jul 1, 1980·The Journal of Investigative Dermatology·G J ThorbeckeT J Flotte

❮ Previous
Next ❯

Citations

Jan 1, 1992·Archives of Dermatological Research·J L ReesP S Friedmann
Jan 1, 1988·Archives of Dermatological Research·R TammiJ E Fräki
Jan 1, 1983·Archives of Dermatological Research·R A Fernandez-BussyJ Thivolet
Jan 1, 1987·Archives of Dermatological Research·C PicutR Lewis
Jan 1, 1988·Archives of Dermatological Research·H SugiuraM Uehara
Jan 1, 1984·Medical Microbiology and Immunology·R G OlsenE J Schulz
Apr 1, 1988·Immunology Today·V B Morhenn
Aug 1, 1985·Journal of the American Academy of Dermatology·D J HoganP R Lane
Nov 1, 1989·Journal of the American Academy of Dermatology·R AshinoffG Lipkin
Aug 13, 2002·Dermatologic Clinics·Erin E Boh, Raed Mahmoud Faleh al-Smadi
Dec 28, 1999·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·I IndrasinghS M Chandi
Nov 7, 2001·Scandinavian Journal of Immunology·B HasséusU I Dahlgren
Feb 15, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·I Rodríguez-NúñezJ G Rey
Jul 1, 1990·Clinical and Experimental Dermatology·A L WrightJ A Hunter
Jun 1, 1996·International Journal of Dermatology·A S al-FouzanA I Rostom
Oct 3, 1998·Experimental Dermatology·G De Panfilis
Nov 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·U KonterW Sterry
Feb 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P M FarthingA T Cruchley
Feb 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·N A Firth, P C Reade
Aug 1, 1984·Journal of Clinical Pathology·J P SloaneR L Powles
Jan 1, 1984·Archives of Dermatological Research·F FacchettiV J Desmet
Aug 1, 1982·American Journal of Ophthalmology·A K BhanC S Foster
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·W A Scherbaum, F J Seif
Oct 1, 1990·Pathology, Research and Practice·J HirotaY Tatemoto
Apr 6, 2011·Current Problems in Surgery·Bohdan PomahacDhruv Singhal
Aug 1, 1984·Journal of the American Academy of Dermatology·N S Penneys
May 1, 1983·Journal of the American Academy of Dermatology·R L ModlinT H Rea
Oct 1, 1984·Journal of the American Academy of Dermatology·W KorkijK Soltani
May 1, 1989·Journal of the American Academy of Dermatology·S MiyagawaK Sakamoto
May 1, 1984·Journal of the American Academy of Dermatology·J E MuhlbauerM C Mihm
Sep 4, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Juliana Tristão WerneckArley Silva Junior
Oct 1, 1985·Oral Surgery, Oral Medicine, and Oral Pathology·J A RegeziJ T Headington
Feb 1, 1983·The Journal of Dermatology·R A Fernandez-BussyJ Thivolet
Nov 1, 1983·The British Journal of Dermatology·B BermanG Petroni
Nov 1, 1982·The Journal of Dermatologic Surgery and Oncology·N F EaglsteinJ E Allen
Sep 1, 1983·The British Journal of Dermatology·G E Pierard, C Pierard-Franchimont
Dec 1, 1983·The British Journal of Dermatology·T J HarristA K Bhan
Dec 1, 1988·The Journal of Dermatology·S MiyagawaK Sakamoto
Aug 1, 1987·The Journal of Dermatology·C W LeeJ I Youn
Jul 1, 1988·International Journal of Dermatology·T ShioharaM Nagashima
Nov 1, 1984·The British Journal of Dermatology·J B MatthewsA J Potts
Nov 1, 1986·Journal of Periodontal Research·G M Newcomb, R N Powell
Jan 1, 1986·Contact Dermatitis·O B ChristensenH I Maibach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.