PMID: 2120136Oct 15, 1990Paper

T-cell subsets, IFN-gamma production and efferent specificity in anti-parental tumor immunity induced by mouse sensitization with xenogenized variant cells

International Journal of Cancer. Journal International Du Cancer
R BianchiP Puccetti

Abstract

In addition to previous evidence for a role of L3T4+ T cells in the protective anti-parental tumor immunity induced by xenogenized variant cells of a murine lymphoma (L5178Y/DTIC), we have investigated the possible participation in this effect of L5178Y tumor-specific lymphocytes of the Lyt-2+ T cell subset. Spleen cells from L5178Y/DTIC tumor-immunized mice produced high levels of IFN-gamma in vitro in response to parental antigens, and this activity was only abolished by treating the responder population with anti-Thy-1.2 antibody or a combination of anti-L3T4 and anti-Lyt-2.2 monoclonal antibodies (MAbs) plus complement. Positively selected L3T4+ and Lyt-2+ cells also produced IFN-gamma in vitro, provided accessory cells (plastic-adherent and Thy-1- Ia- splenocytes, respectively) were added to the lymphocyte-tumor cell cocultures. The production of IFN-gamma by purified L3T4+ and Lyt-2+ cells was inhibited by addition of the respective anti-class-II and anti-class-I H-2 antibody to the cultures. Administration of anti-IFN-gamma MAb in vivo significantly impaired the resistance of L5178Y/DTIC-immune mice to challenge with parental cells, as manifested by survival criteria and increased tumor-cell proliferation in the spleens ...Continue Reading

References

May 1, 1978·Journal of the National Cancer Institute·C RiccardiE Bonmassar
Feb 15, 1989·International Journal of Cancer. Journal International Du Cancer·P PuccettiM C Fioretti
Jan 1, 1989·Advances in Immunology·T R Mosmann, R L Coffman
Jul 15, 1988·International Journal of Cancer. Journal International Du Cancer·R BianchiM C Fioretti
Jan 1, 1987·Cancer Metastasis Reviews·P PuccettiM C Fioretti
Jul 15, 1987·International Journal of Cancer. Journal International Du Cancer·R BianchiM C Fioretti
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·L RomaniM G Mage
Aug 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·E BonmassarA Goldin
Jan 1, 1983·Advances in Cancer Research·T Boon

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Citations

Jul 1, 1992·International Journal of Immunopharmacology·R BianchiP Puccetti
Sep 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R BianchiP Puccetti
Jan 10, 2013·PloS One·Javier MercapideAurelio Lorico
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca FallarinoPaolo Puccetti

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