T-cell subsets in adenoids and peripheral blood related to age, otitis media with effusion and allergy

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
E LaggingM van Hage-Hamsten

Abstract

Adenoids and peripheral blood samples from 29 children (20-120 months of age) undergoing adenoidectomy for long-standing otitis media with effusion (OME) (n=16) or obstructive adenoid hyperplasia (n=13) were investigated by flow cytometry for their T-lymphocyte profile. Eleven of the enrolled children were allergic to inhalant and/or food allergens. For the whole group, the percentage of helper T cells belonging to the memory phenotype (CD4+/CD45RO+ cells) was significantly higher in adenoids than in blood (p<0.0001), while the same cell category increased with age in peripheral blood (p<0.01). A highly significant negative regression (p<0.001) was found between age and the percentage ratio of CD4+ cells that were CD45RO+ in adenoids and blood. Allergic children had a higher CD4+/CD8+ ratio for cells expressing CD45RO+ (p<0.05) in adenoids. The results of this study indicate that adenoids participate in the development of an immunological memory. Our findings support a relationship between allergy and memory cells in adenoids.

References

Feb 1, 1990·Clinical and Experimental Immunology·E B van NieuwkerkS van der Baan
Jan 1, 1987·The Journal of Allergy and Clinical Immunology·D P SkonerP Fireman
Jul 1, 1985·International Journal of Pediatric Otorhinolaryngology·N Black
Jan 1, 1984·Acta Oto-laryngologica. Supplementum·D BoedtsJ Van Vuchelen
Feb 1, 1981·The British Journal of Radiology·W D JeansB C Leighton
Dec 1, 1995·Journal of Leukocyte Biology·A BengtssonA Scheynius
Dec 1, 1995·The Journal of Experimental Medicine·G Del PreteS Romagnani
Oct 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M G KarlssonH B Hellquist
Mar 1, 1995·The Annals of Otology, Rhinology, and Laryngology·J ForsgrenB Christensson
Aug 1, 1993·Archives of Otolaryngology--head & Neck Surgery·L Brodsky, R J Koch
Jul 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C HemlinA Scheynius
Jan 1, 1993·Advances in Immunology·C R Mackay
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·R U PawankarC Ra
Apr 1, 1996·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J M Bernstein
Oct 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P S Mattila, J Tarkkanen

❮ Previous
Next ❯

Citations

Sep 12, 2013·Current Allergy and Asthma Reports·Sharad K Sharma, Michael E Pichichero
May 30, 2001·International Journal of Pediatric Otorhinolaryngology·M MusiatowiczE Hassmann
Mar 14, 2003·International Journal of Pediatric Otorhinolaryngology·Jolanta WysockaMarcin Musiatowicz
Jul 15, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Bozena SkotnickaEdwina Kasprzycka
Dec 25, 2007·International Journal of Pediatric Otorhinolaryngology·Ilona BauerKarol Ratomski
Oct 16, 2004·Expert Review of Anti-infective Therapy·Artem JavadyanDimitris A Kafetzis
Mar 10, 2001·Acta Paediatrica·E NormannB Wettergren
Jan 24, 2006·Acta Oto-laryngologica·Georgios PapatziamosClaes Hemlin
Nov 10, 2011·International Journal of Immunopathology and Pharmacology·G L MarsegliaA M Castellazzi
Feb 17, 2019·International Journal of Pediatric Otorhinolaryngology·Jessica Jane BrowneJennelle Maree Kyd

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved