T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

Oncoimmunology
Alexander Pedroza-GonzalezDave Sprengers

Abstract

Recently, we reported the accumulation of CD4+FOXP3+ regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression mediated by TiTregs.

References

Mar 24, 2009·Annual Review of Immunology·Ian Nicholas Crispe
Sep 18, 2009·Advances in Experimental Medicine and Biology·Giuseppe Nocentini, Carlo Riccardi
Feb 23, 2011·The Journal of Experimental Medicine·Alexander Pedroza-GonzalezA Karolina Palucka
Mar 23, 2012·Nature Reviews. Cancer·Karolina Palucka, Jacques Banchereau
Jun 22, 2012·Oncoimmunology·Angela D Pardee, Lisa H Butterfield
Aug 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexander Pedroza-GonzalezDave Sprengers

Citations

Sep 11, 2014·Biochimica Et Biophysica Acta·Pratika Y HernandaQiuwei Pan
Aug 7, 2019·Therapeutic Advances in Medical Oncology·Weiqi XuJiansong Ji
May 31, 2018·Journal of Experimental & Clinical Cancer Research : CR·Feng XuChaoliu Dai

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