PMID: 9539772May 16, 1998Paper

T cell vaccination induces T cell receptor Vbeta-specific Qa-1-restricted regulatory CD8(+) T cells

Proceedings of the National Academy of Sciences of the United States of America
H JiangL Chess

Abstract

Vaccination of mice with activated autoantigen-reactive CD4(+) T cells (T cell vaccination, TCV) has been shown to induce protection from the subsequent induction of a variety of experimental autoimmune diseases, including experimental allergic encephalomyelitis (EAE). Although the mechanisms involved in TCV-mediated protection are not completely known, there is some evidence that TCV induces CD8(+) regulatory T cells that are specific for pathogenic CD4(+) T cells. Previously, we demonstrated that, after superantigen administration in vivo, CD8(+) T cells emerge that preferentially lyse and regulate activated autologous CD4(+) T cells in a T cell receptor (TCR) Vbeta-specific manner. This TCR Vbeta-specific regulation is not observed in beta2-microglobulin-deficient mice and is inhibited, in vitro, by antibody to Qa-1. We now show that similar Vbeta8-specific Qa-1-restricted CD8(+) T cells are also induced by TCV with activated CD4(+) Vbeta8(+) T cells. These CD8(+) T cells specifically lyse murine or human transfectants coexpressing Qa-1 and murine TCR Vbeta8. Further, CD8(+) T cell hybridoma clones generated from B10.PL mice vaccinated with a myelin basic protein-specific CD4(+)Vbeta8(+) T cell clone specifically recognize o...Continue Reading

References

Jan 1, 1992·Annual Review of Immunology·B R BloomP Salgame
Nov 1, 1988·Immunology Today·I R Cohen, H L Weiner
Jan 1, 1983·Annual Review of Immunology·D R GreenR K Gershon
Jan 1, 1982·Immunogenetics·T H Stanton, S Carbon
Jan 1, 1984·Annual Review of Immunology·M E Dorf, B Benacerraf
Dec 1, 1995·International Archives of Allergy and Immunology·F Mor, I R Cohen
Mar 1, 1994·International Immunology·S Sanderson, N Shastri
Sep 1, 1996·The Journal of Experimental Medicine·N K Nanda, E Sercarz

❮ Previous
Next ❯

Citations

Dec 23, 1998·European Journal of Immunology·M SalcedoJ P Abastado
Mar 29, 2002·European Journal of Immunology·Pilar GarcíaMiguel López-Botet
Nov 16, 2007·Journal of Neurology·Christoph KleinschnitzHeinz Wiendl
Apr 3, 2012·Immunologic Research·Keren Rabinowitz, Lloyd Mayer
Dec 5, 2000·Current Opinion in Immunology·M G Roncarolo, M K Levings
Jan 23, 1999·Current Opinion in Immunology·D M Kemeny
Oct 6, 1999·Current Opinion in Immunology·Y Zhai, J W Kupiec-Weglinski
Feb 27, 1999·Current Opinion in Immunology·V M BraudA J McMichael
Feb 25, 2009·Immunology and Cell Biology·Yuan Min Wang, Stephen I Alexander
Apr 21, 2004·Nature Immunology·Dan HuHarvey Cantor
Mar 17, 2006·The New England Journal of Medicine·Hong Jiang, Leonard Chess
Dec 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Linrong LuHarvey Cantor
Sep 30, 2010·The Journal of Clinical Investigation·Luc Van Kaer
Dec 25, 2008·PloS One·Francisco J QuintanaIrun R Cohen
Apr 12, 2012·Journal of the American Society of Nephrology : JASN·Yuan Min WangStephen I Alexander
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·H JiangL Chess
Aug 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Reinhard Hohlfeld, Hartmut Wekerle
Jun 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·H JiangL Chess
Mar 20, 2010·Seminars in Immunopathology·Trina A JohnsonSylvie Fournier
Jun 15, 2011·Cellular and Molecular Life Sciences : CMLS·Sue TsaiPere Santamaria
Mar 26, 2005·Immunological Reviews·Silke Paust, Harvey Cantor
May 20, 2003·Immunological Reviews·Thomas A FergusonThomas S Griffith
Aug 15, 2006·Immunological Reviews·Linrong LuHarvey Cantor
Sep 16, 2006·Immunological Reviews·Thomas A Ferguson, Thomas S Griffith
Nov 3, 2004·The Journal of Clinical Investigation·Stefanie SarantopoulosHarvey Cantor
Nov 3, 2004·The Journal of Clinical Investigation·Vipin Kumar
Nov 3, 2004·The Journal of Clinical Investigation·Hong Jiang, Leonard Chess
Jan 26, 2005·The Journal of Clinical Investigation·Hong JiangLeonard Chess
Oct 3, 2003·The Journal of Clinical Investigation·Nader NajafianSamia J Khoury
Apr 16, 2004·The Journal of Clinical Investigation·Vily PanoutsakopoulouHarvey Cantor
Nov 21, 2015·Neurology. Neuroimmunology and Neuroinflammation·Sterling B OrtegaNitin J Karandikar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.