T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma

Rare Tumors
Pooja AdvaniHan W Tun

Abstract

Primary central nervous system (PCNSL) lymphoma is an aggressive extranodal non-Hodgkin lymphoma, and most cases are classified as diffuse large B-cell lymphoma (DLBCL) by histology. T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) represents a distinct subtype of diffuse large B-cell lymphoma and is characterized by the presence of scattered large neoplastic B-cells in a background of abundant T-cells and histiocytes. This is in contrast to the dense perivascular cuffing of neoplastic B-cells in classic DLBCL. T-cell/histiocyte-rich large B-cell lymphoma should be considered in PCNSL cases in which neoplastic B-cells are sparse and scattered. Immunohistochemistry will help identify the B-cells and surrounding infiltrate rich in Tlymphocytes and histiocytes. Future studies exploring the biology of TCRLBCL and the crosstalk between the neoplastic cells and the surrounding inflammatory infiltrate may provide exciting prospects for future therapies for TCRLBCL.

References

Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R BouabdallahL Xerri
Dec 1, 2006·Neurosurgical Focus·Deborah L Commins
Jan 11, 2008·Blood·Han W TunMichael McKinney
Nov 4, 2008·Archives of Pathology & Laboratory Medicine·Sharathkumar Bhagavathi, Jon D Wilson
Jan 6, 2009·Blood·James L RubensteinMarc A Shuman
May 27, 2011·Blood·Andrés J M Ferreri

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Citations

Jul 19, 2018·Head and Neck Pathology·Ricardo Natã Fonseca SilvaNadia Lago Costa

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT01722305

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