PMID: 9552138Apr 29, 1998Paper

T-cells and HLA-class II expression in the large intestine of infants in the early postnatal period

Journal of Pediatric Gastroenterology and Nutrition
T OrmäläE Savilahti

Abstract

There is only limited knowledge of the development of the immune responses of the gut in very young infants after exposure to bacterial and food antigens at birth. In this study, 49 large intestinal biopsy specimens, which were judged to have normal morphology, were taken from 49 young infants. Eleven patients had Hirschsprung's disease (group 1) and 38 had miscellaneous conditions (group 2). The densities of T cells, their subsets expressing surface antigens CD8 and CD4, and T-cell receptors alpha/beta or gamma/beta were measured, as well as densities of mononuclear and epithelial cells expressing HLA-class II antigens. T-cell densities in groups 1 and 2 were similar. Patients with Hirschsprung's disease had significantly more HLA-DR (p = 0.006) and HLA-DP-expressing cells (p = 0.003) in the lamina propria than did the patients in group 2. In group 1, HLA-DR- (r = 0.58; p = 0.46) and HLA-DP-expressing cells (r = 0.66; p = 0.03) showed a significant positive regression with age in the lamina propria, whereas in group 2, HLA-DR+ cells in the lamina propria showed marked (r = -0.9; p = 0.006) negative regression during the first 1.5 months of life. In contrast to results in previous reports, in the current results, HLA-D region a...Continue Reading

References

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Citations

Sep 25, 2001·Journal of Pediatric Gastroenterology and Nutrition·T OrmäläE Savilahti
Aug 10, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·G HacsekE Savilahti
May 5, 2004·Best Practice & Research. Clinical Gastroenterology·Karen M PickardThomas T MacDonald
Aug 9, 2005·Gastroenterology Clinics of North America·Thomas T MacDonald, John N Gordon
Feb 25, 2003·Critical Care Nursing Clinics of North America·Frances Strodtbeck
May 18, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jose M Saavedra

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