T cells, B cells, and PD-L1 expression in esophageal and gastric adenocarcinoma before and after neoadjuvant chemotherapy: relationship with histopathological response and survival.

Oncoimmunology
Maria Christina SvenssonKarin Jirström

Abstract

Perioperative chemotherapy enhances the survival rates for patients with esophageal and gastric (EG) adenocarcinoma, but not all patients benefit from this additional treatment. Chemotherapeutic agents have been demonstrated to alter the immune cell (IC) composition in the tumor microenvironment. Hence, there is a rationale to investigate the influence of neoadjuvant chemotherapy (NAC) on different IC subsets, to better understand and compare their utility as complementary prognostic or predictive biomarkers in a clinically relevant context. The density of T cells (CD8+ and FoxP3+), B cells (CD20+) and the expression of PD-L1 on ICs and tumor cells (TC) was assessed by immunohistochemistry on paired biopsies from primary tumors (PT) pre-NAC, and resected PT and lymph node metastases post-NAC. The cohort encompasses 148 patients with resectable EG adenocarcinoma, all of whom received NAC. The density of CD8+ cells was decreased and the density of FoxP3+ cells and CD20+ cells was increased in PT post-NAC. PD-L1 expression was not altered following NAC. In pre-NAC specimens, high FoxP3+ density and high PD-L1 expression on ICs were favorable prognostic factors, whereas high CD8+ density was an unfavorable prognostic factor. In pos...Continue Reading

References

Mar 22, 2006·Nature Immunology·Danielle L DraytonNancy H Ruddle
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sylvain LadoireFrançois Ghiringhelli
Jun 1, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·U ZinggD Oertli
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc YchouPhilippe Rougier
Nov 30, 2014·Breast Cancer Research : BCR·Elena García-MartínezFrancisco Ayala de la Peña
Mar 25, 2016·Oncotarget·Christine BögerChristoph Röcken
Mar 27, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masaki MandaiIkuo Konishi
Sep 8, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charlotte S LoBrad H Nelson
Jan 13, 2017·Journal of Gastrointestinal Oncology·Richard FristedtKarin Jirström
Jun 16, 2017·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Irene GulloGabriela M Almeida
Jul 10, 2017·The Journal of Surgical Research·Chie SakimuraMasaichi Ohira
Dec 2, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Janis M TaubeAshley Cimino-Mathews
Nov 13, 2019·Archives of Pathology & Laboratory Medicine·Eric E WalkUNKNOWN College of American Pathologists Personalized Health Care Committee

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