PMID: 11898528Mar 20, 2002Paper

T cells, cytokines, and autoantigens in multiple sclerosis

Current Neurology and Neuroscience Reports
B Gran, A Rostami

Abstract

In multiple sclerosis (MS), inflammatory demyelination in the central nervous system is thought to be initiated by T cells that recognize myelin antigens. T cells are the main regulators of acquired immunity and are involved in the pathogenesis of several organ-specific autoimmune diseases. This review provides an overview of recent studies on the role of T cells in autoimmune demyelination. Because autoreactive T cells are normally present in the mature repertoire of T cells in the blood and lymphoid organs of MS patients, but also in normal controls, particular attention is devoted to the mechanisms of activation and the functional phenotype of such T cells in patients with MS. The role of cytokines as effector molecules and the main candidate antigens are also discussed.

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Citations

May 3, 2003·Diabetes Technology & Therapeutics·Douglas L Feinstein
Oct 7, 2005·International Journal of Hematology·Shinji NakaoChiharu Sugimori
Jul 3, 2007·Journal of the Neurological Sciences·S Michael PhillipsAbdolmohamad Rostami
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Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bruno GranAbdolmohamad Rostami
Feb 8, 2021·Journal of Neuroimmunology·Duygu Eryavuz OnmazAli Unlu
Jan 4, 2017·Molecular Pharmaceutics·Laura NorthrupCory Berkland

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