T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to alpha-galactosylceramide are impaired.

Journal of the Neurological Sciences
Joan O'KeeffeE L Hogan

Abstract

Multiple sclerosis (MS) is an autoimmune disorder characterised by clinical relapse and remission and pathological demyelination with varying inflammation. Because it is suggested that T-cells expressing natural killer cell receptors (NKR) play important roles in regulating human autoimmune diseases, we have quantified populations of T-cells expressing the NKR CD56, CD161 and CD94 in the peripheral blood of MS patients, in healthy control subjects (HS) and in patients with other neurological diseases (OND). CD161(+) T-cells and CD94(+) T-cells were significantly decreased in MS patients with primary progressive disease and secondary progressive disease respectively whereas CD56(+) T-cell numbers were unchanged. In contrast NKT-cells that express the invariant Valpha24-Jalpha18(+) T-cell receptor identified here by specific receptor antibody and CD1d-tetrameric PBS57-loaded complexes, were increased in MS patients compared with HS. Reductions in CD161(+) T-cells and CD94(+) T-cells relative to HS were also observed in the OND group and this was particularly prominent in Parkinsonian patients. A striking functional finding was that while NKT-cells in unfractionated peripheral blood from healthy subjects expanded in number and pro...Continue Reading

References

Dec 1, 1996·The Journal of Experimental Medicine·S D WolfC A Janeway
Dec 31, 1997·The Journal of Experimental Medicine·B ZhangT Tabira
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·N LeeD E Geraghty
Jun 6, 2000·The Journal of Experimental Medicine·K BenlaghaA Bendelac
Jan 6, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R GauslingD A Hafler
Dec 19, 2001·The Journal of Experimental Medicine·A W JahngV Kumar
Jan 29, 2002·Nature Immunology·Janice M MoserAron E Lukacher
Mar 1, 2002·Immunologic Research·Niels HellingsPiet Stinissen
Mar 6, 2002·The Journal of Experimental Medicine·Jenny E GumperzMichael B Brenner
Nov 21, 2002·European Journal of Immunology·Matthew J LozaBice Perussia
Feb 13, 2003·International Immunology·Manabu ArakiTakashi Yamamura
Jun 10, 2004·Immunology and Cell Biology·Luc Van Kaer
Mar 18, 2005·Annual Review of Immunology·Mitchell Kronenberg
Sep 24, 2005·Current Drug Targets. Immune, Endocrine and Metabolic Disorders·Sachiko Miyake, Takashi Yamamura
Mar 3, 2006·The New England Journal of Medicine·Elliot M FrohmanCedric S Raine
May 13, 2006·Human Immunology·Loes LinsenPiet Stinissen
Jun 30, 2006·Cancer Science·Ken-ichiro SeinoMasaru Taniguchi
Dec 19, 2006·Immunologic Research·Francisco BorregoJohn E Coligan
Feb 1, 2008·Journal of Neuroimmunology·Jorge Correale, Andrés Villa

❮ Previous
Next ❯

Citations

May 16, 2015·Immunology·Joan O'KeeffeEdward L Hogan
Mar 8, 2014·Immunopharmacology and Immunotoxicology·Maryam RoozbehAbbas Mirshafiey
May 29, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Nicholas E MartinezIkuo Tsunoda
Mar 30, 2013·Journal of Neuroimmunology·Carol M GatelyJoan O'Keeffe
Aug 21, 2009·Multiple Sclerosis : Clinical and Laboratory Research·M Podbielska, E L Hogan
Sep 22, 2017·International Reviews of Immunology·Carolina SchäferLeandro J Carreño
Jan 1, 2013·Brain Sciences·Maria PodbielskaEdward L Hogan
Jul 6, 2013·Molecular Nutrition & Food Research·David BalgomaCraig E Wheelock
Jun 26, 2012·Immunological Reviews·Lior MayoHoward L Weiner
Mar 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margaret A JordanAlan G Baxter
Mar 1, 2012·Annals of Saudi Medicine·Mohammad Kazemi ArababadiGholamhossein Hassanshahi
Jun 25, 2019·Frontiers in Cellular Neuroscience·Yu Cui, Qi Wan
Jul 3, 2021·Cells·Emily E S Brettschneider, Masaki Terabe
Jul 25, 2021·International Journal of Molecular Sciences·Maria PodbielskaAnna Pokryszko-Dragan
Aug 14, 2021·Neurology. Neuroimmunology and Neuroinflammation·Belinda CarriónShohreh Issazadeh-Navikas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2022 Meta ULC. All rights reserved