T Cells in Fibrosis and Fibrotic Diseases.

Frontiers in Immunology
Mengjuan Zhang, Song Zhang

Abstract

Fibrosis is the extensive deposition of fibrous connective tissue, and it is characterized by the accumulation of collagen and other extracellular matrix (ECM) components. Fibrosis is essential for wound healing and tissue repair in response to a variety of triggers, which include infection, inflammation, autoimmune disorder, degenerative disease, tumor, and injury. Fibrotic remodeling in various diseases, such as liver cirrhosis, pulmonary fibrosis, renal interstitial fibrosis, myocardial infarction, systemic sclerosis (SSc), and graft-versus-host disease (GVHD), can impair organ function, causing high morbidity and mortality. Both innate and adaptive immunity are involved in fibrogenesis. Although the roles of macrophages in fibrogenesis have been studied for many years, the underlying mechanisms concerning the manner in which T cells regulate fibrosis are not completely understood. The T cell receptor (TCR) engages the antigen and shapes the repertoire of antigen-specific T cells. Based on the divergent expression of surface molecules and cell functions, T cells are subdivided into natural killer T (NKT) cells, γδ T cells, CD8+ cytotoxic T lymphocytes (CTL), regulatory T (Treg) cells, T follicular regulatory (Tfr) cells, and...Continue Reading

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Citations

Mar 18, 2021·Drug Design, Development and Therapy·Kenia UbietaLutz Wollin
Jun 3, 2021·International Journal of Molecular Sciences·Can HuangPatricia Santofimia-Castaño
Jun 3, 2021·International Journal of Molecular Sciences·Kyoko OuraTsutomu Masaki
Jul 3, 2021·International Journal of Molecular Sciences·Yoko OgawaKazuo Tsubota
Jul 3, 2021·International Journal of Molecular Sciences·Tanyalak ParimonChangfu Yao
May 28, 2021·Journal of the American Academy of Dermatology·Celina DubinEmma Guttman-Yassky
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Jul 27, 2021·The Journal of Veterinary Medical Science·Satoshi MatsuyamaJyoji Yamate
Apr 18, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gyu Seong HeoYongjian Liu

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Methods Mentioned

BETA
bronchoalveolar
lavage
bronchoalveolar lavage
biopsies

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