T cells in the pathogenesis of systemic lupus erythematosus

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Robert W Hoffman

Abstract

Recent studies in patients with systemic lupus erythematosus (SLE) have demonstrated that autoantigen-reactive T cells can be isolated from peripheral blood and that such cells can support autoantibody production ex vivo, suggesting that they may have a central role in the pathogenesis of disease. In addition, recent work has identified and characterized signaling abnormalities in T cells from SLE that may be fundamental to the disease. This review will examine the role of T cells in the pathogenesis of SLE and it will consider pathogenic mechanisms by which T cells escape normal of immunological tolerance. The focus will be on recent studies characterizing autoantigen-reactive human T cells and signaling abnormalities identified in T cells from patients with SLE.

Citations

Jul 28, 2006·Rheumatology International·Min-Young HerSang-Cheol Bae
Mar 18, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Monika EdelbauerLothar Bernd Zimmerhackl
Jan 19, 2006·Journal of Clinical Immunology·Dirk LangnickelGabriela Riemekasten
May 2, 2008·Archives of Pharmacal Research·Byeong Suk ChaeJae Heon Yang
Dec 13, 2005·Autoimmunity Reviews·Akaluck Thatayatikom, Andrew J White
Jan 11, 2012·Immunology and Cell Biology·Fabien B VincentFabienne Mackay
Jan 4, 2008·Immunology and Cell Biology·Joanna Groom, Fabienne Mackay
Aug 1, 2007·The Journal of Experimental Medicine·Joanna R GroomFabienne Mackay
Sep 9, 2005·Current Opinion in Lipidology·Sander I van LeuvenErik S Stroes
Aug 27, 2009·The Journal of Pharmacology and Experimental Therapeutics·Thomas B SundbergGary D Glick
Mar 15, 2006·Annals of the Rheumatic Diseases·S Mellor-PitaJ A Vargas
Oct 13, 2011·Arthritis Research & Therapy·Simanta Pathak, Chandra Mohan
Jan 4, 2013·PloS One·Xinzhou ZhangYong Dai
Nov 13, 2013·Rheumatology International·Ashwaq Ale'edSulaiman M Al-Mayouf
Jul 4, 2012·Molecular Immunology·Monika Pavkova GoldbergovaPetr Nemec
Jan 11, 2011·Journal of Autoimmunity·Carrie A FletcherFabienne Mackay
Feb 13, 2009·The Journal of Investigative Dermatology·Rikke Baek SørensenMads Hald Andersen
Mar 6, 2007·Seminars in Nephrology·Mary H Foster
Apr 29, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Robert W Hoffman, Marcos E Maldonado
Jun 8, 2007·La Revue de médecine interne·F Monneaux, S Muller
Feb 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marielle ThewissenPiet Stinissen
Oct 19, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Therese VallerskogChristina Trollmo
Feb 10, 2009·Cytometry. Part B, Clinical Cytometry·Susana Mellor-PitaJuan A Vargas
Oct 30, 2008·European Journal of Immunology·Yackov BerkunDror Mevorach
Nov 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Utako KanekoMakoto Uchiyama
Jun 25, 2013·Scandinavian Journal of Immunology·C M CabreraJ Zamorano
Sep 13, 2005·Trends in Immunology·Ram Raj Singh
Sep 20, 2005·Trends in Immunology·Jennifer A Croker, Robert P Kimberly
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Eric L Greidinger, Robert W Hoffman

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