T cells mediate cross-protective immunity between spotted fever group rickettsiae and typhus group rickettsiae

The Journal of Infectious Diseases
Gustavo ValbuenaDavid H Walker

Abstract

Rickettsioses are severe infections caused by obligately intracellular bacteria that preferentially infect the endothelium lining the vasculature. The causative agents, rickettsiae, have been divided according to biological, genetic, and antigenic parameters into 2 main groups: spotted fever and typhus. They have not been thought to stimulate cross-reactive protective immune responses; however, in this study, we show that, in relevant animal models that mimic human rickettsial infections, there is reciprocal immunological cross-protection between spotted fever group and typhus group rickettsiae. Furthermore, we present evidence that T cells are responsible for this cross-immunity and that cross-stimulation of T cells also occurs in humans.

Citations

Apr 17, 2008·Nature Reviews. Microbiology·David H Walker, Nahed Ismail
Sep 26, 2013·Future Microbiology·Sanjeev K SahniDavid H Walker
Jul 13, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Yassina BechahDidier Raoult
Feb 17, 2006·Annals of the New York Academy of Sciences·Christopher D Paddock
Aug 1, 2006·Thrombosis Research·Sanjeev K Sahni
Mar 16, 2016·Infection and Immunity·Anke OsterlohBernhard Fleischer
Aug 5, 2017·Medical Microbiology and Immunology·Anke Osterloh
Oct 23, 2020·PLoS Neglected Tropical Diseases·Anke Osterloh

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