PMID: 6972043Mar 1, 1981Paper

T cells respond preferentially to antigens that are similar to self H-2

Proceedings of the National Academy of Sciences of the United States of America
M J Bevan, T Hünig

Abstract

We have constructed bone marrow irradiation chimeras to investigate the influence of self antigens on the specificity of the T lymphocyte receptor repertoire. Bone marrow cells from (A X B)F1 mice heterozygous for the major histocompatibility genes were allowed to mature into T cells in irradiated parent A or parent B strains. More than 8 weeks after irradiation, when the lymphoid system had regenerated from the F1 stem cells, the degree of T cell reactivity to mutant major histocompatibility antigens, A', was assessed. It was found that T cells that had matured in the irradiated A mice, [F1 leads to A] chimeras, responded better to A' antigen than did T cells from the [F1 leads to B] chimeras. Because the mutant histocompatibility antigen A' is very similar in structure to A, differing only by one or a few residues, this suggests that the T cell repertoire in [F1 leads to parent] chimeras reacts preferentially with foreign antigens that are slight variants of the self antigens expressed on radiation-resistant cells--probably cells in the thymus.

References

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Citations

Feb 1, 1992·Medical Hypotheses·B Daunter
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R E Gress, R J Hodes
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W C ShaD Y Loh
Jan 1, 1982·The Journal of Experimental Medicine·T R Hünig, M J Bevan
Sep 7, 1995·Annals of the New York Academy of Sciences·H Von Boehmer
Jun 8, 1999·Annual Review of Immunology·E SebzdaP S Ohashi
Jul 1, 1983·Annales d'immunologie·H von BoehmerW Haas
May 1, 1985·Medical Hypotheses·B Daunter
Jan 31, 2006·Toxicology and Applied Pharmacology·Alexander M RoweJohn B Barnett
Jan 22, 1998·Clinical Immunology and Immunopathology·W M Ridgway, C G Fathman
Jan 13, 2010·Immunity·Whitney A MacdonaldJames McCluskey
Nov 1, 1981·Immunology Today·M J Bevan
Jan 12, 2013·Protein & Cell·Lei YinPhilippa Marrack
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·I MessaoudiJ Nikolich-Zugich
Oct 1, 1982·European Journal of Immunology·H Von BoehmerJ Langhorne

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