T cells specific for the triggering virus infiltrate the eye in patients with herpes simplex virus-mediated acute retinal necrosis

The Journal of Infectious Diseases
Georges M G M VerjansA D Osterhaus

Abstract

Acute retinal necrosis (ARN) is a rare, potentially blinding retinal disease resulting from ocular infections with herpes simplex virus (HSV) or varicella-zoster virus (VZV). To determine the antigen specificity and functional characteristics of ocular infiltrating T cells in ARN, T cells were isolated and expanded nonspecifically from intraocular fluid (IOF) samples from 2 patients with HSV-1- and 3 with VZV-mediated ARN. HSV-specific T cell reactivity could be detected only in the IOF-derived T cell lines (TCLs) of the 2 patients with HSV-mediated ARN. These TCLs consisted of both HSV type-common and type-specific CD4+ and CD8+ T cell clones (TCCs) with differential T cell receptor usage. Irrespective of their phenotype, the TCCs were cytolytic and secreted interferon-gamma, tumor necrosis factor-alpha, interleukin-4, and interleukin-5. In both patients, the antigen specificity of a substantial number of HSV-1-specific TCCs could be mapped to approximately 0.67-0.73 HSV-1 map units. The data presented suggest the contribution of T cells, specific for the triggering virus, to the pathogenesis of ARN.

Citations

Jan 16, 2002·The Pediatric Infectious Disease Journal·Sharon Chen, Geoffrey A Weinberg
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Georges M G M VerjansAlbert D M E Osterhaus
May 15, 2013·Current Opinion in Virology·Werner J D OuwendijkDavid M Koelle
Nov 13, 2014·Journal of Neurovirology·Christina M KolliasStephen R Jennings
Mar 16, 2018·Ocular Immunology and Inflammation·Jolanda D F De Groot-MijnesGeorges M G M Verjans
Mar 14, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Werner J D OuwendijkGeorges M G M Verjans
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min XuRobert L Hendricks

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