PMID: 6965305Jan 1, 1980Paper

T cells that encounter virus in the complete absence of a particular H-2 antigen are nonresponsive when stimulated again in the context of that H-2 antigen

The Journal of Experimental Medicine
J R Bennink, P C Doherty

Abstract

Immunologically naive BALB/c (H-2d) and C57BL/6J (B6) (H-2b) T-cell populations can, after filtration to remove alloreactive precursor lymphocytes, be induced to respond to vaccinia virus presented in the context of H-2Kk when stimulated in an appropriate recipient. Exposure to vaccinia virus 6 wk previously completely abrogated the capacity of BALB/c T cells to interact with H-2Kk-vaccinia virus. This is also true for negatively selected B6 thoracic duct lymphocytes taken at 14 or 18 d, but not at 6 wk after immunization: the discrepancy is thought to reflect the progressive emergence of new T cells in the latter group. No evidence could be found for the operation of suppression, and the results are considered to indicate that T cells that interact with virus in the absence of the relevant H-2 antigen are tolerized. Whereas stimulation to effector function is H-2 restricted, induction of immune paralysis may be unrestricted. The capacity of T-cell populations to respond to virus presented in the context of allogeneic H-2 determinants thus depends upon previous antigenic experience.

References

Jan 1, 1976·Scandinavian Journal of Immunology·C A JanewayH Binz
Dec 21, 1978·Nature·J R Bennink, P C Doherty
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J R Bennink, P C Doherty
May 1, 1979·European Journal of Immunology·I Nakamura, G Cudkowicz
Jan 1, 1978·The Journal of Experimental Medicine·G E HatchD B Menzel

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