Abstract
Fas-mediated apoptosis is essential for activation-induced cell death of alpha/beta T cells, but it is not clear what role, if any, it plays in regulating other components of the immune system. To study the role of Fas in gamma/delta T cell development, Fas-deficient lpr mice were bred with T cell receptor alpha gene-ablated (TCR-alpha-/-) mice to generate mice deficient in one or both genes. The TCR-alpha-/-, lpr/lpr mice had a nearly 10-fold increase in total lymph node cell (LNC) number compared with Fas-intact TCR-alpha-/- mice, because of expansion of TCR-gamma/delta+ and TCR-beta+ cells. In Fas-intact TCR-alpha-/- mice, approximately one third of the LNCs expressed TCR-gamma/delta. These were evenly divided between the CD4-, CD8-alpha+ and the CD4-, CD8- subsets, and rarely expressed the B220 epitope of CD45. In contrast, in TCR-alpha-/-, lpr/lpr mice, TCR-gamma/delta+ cells comprised half of the LNCs and were primarily CD4-, CD8-, and B220+. Moreover, Fas deficiency in TCR-alpha-/- mice caused a preferential expansion of gamma/delta T cells expressing variable region genes characteristic of intestinal intraepithelial lymphocytes. These results demonstrate a role for Fas in regulating the gamma/delta T cell contribution t...Continue Reading
References
Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Mar 26, 1992·Nature·R Watanabe-FukunagaS Nagata
Oct 1, 1992·The Journal of Experimental Medicine·T ZhouJ D Mountz
Feb 1, 1992·European Journal of Immunology·C L SidmanH Von Boehmer
Jun 5, 1992·Science·K L PhilpottM J Owen
Dec 1, 1990·The Journal of Experimental Medicine·J D MountzH Blüthmann
Jul 26, 1991·Cell·N ItohS Nagata
Feb 22, 1990·Nature·A L DentS M Hedrick
Jul 1, 1990·The Journal of Experimental Medicine·T OhtekiK Kumagai
Oct 19, 1990·Cell·L LefrancoisT Goodman
Sep 29, 1988·Nature·W L Havran, J P Allison
May 1, 1989·The Journal of Experimental Medicine·S YoneharaM Yonehara
Nov 1, 1989·The Journal of Experimental Medicine·T Goodman, L Lefrancois
Jul 21, 1989·Science·B C TrauthP H Krammer
Aug 1, 1985·European Journal of Immunology·D A NemazeeM Kiefer
Dec 6, 1984·Nature·S P CobboldH Waldmann
Feb 19, 1981·Nature·R L Coffman, I L Weissman
Apr 1, 1994·International Immunology·L HuangI N Crispe
Aug 1, 1994·Immunity·I N Crispe
Aug 1, 1994·Immunity·G G Singer, A K Abbas
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M AdachiS Nagata
Aug 1, 1993·The Journal of Experimental Medicine·J WuJ D Mountz
Jun 1, 1993·International Immunology·C KlasP H Krammer
Aug 26, 1993·Nature·J OgasawaraS Nagata
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J DrappaK B Elkon
Dec 1, 1994·Immunity·L HuangI N Crispe
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L VineyM J Owen
Feb 1, 1994·Seminars in Immunology·N Van Houten, R C Budd
May 7, 1993·Cell·C A MallickA C Hayday
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J H RussellR Wang
Citations
Sep 24, 1999·Immunologic Research·I N Crispe
Dec 16, 2000·Springer Seminars in Immunopathology·C MillerA C Hayday
Jul 25, 2000·Developmental and Comparative Immunology·M D EisenbraunR A Miller
Jan 23, 1999·Current Opinion in Immunology·D M Kemeny
May 1, 1996·The Journal of Experimental Medicine·L WenA C Hayday
Sep 1, 1996·The Journal of Experimental Medicine·S L PengJ Craft
Jun 3, 2000·Annual Review of Immunology·A C Hayday
Sep 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Beverly W BaronJoseph M Baron
Dec 1, 1996·The Journal of Experimental Medicine·M SzczepanikP W Askenase
Dec 31, 1997·The Journal of Experimental Medicine·A MizoguchiA K Bhan
Aug 13, 2009·International Immunopharmacology·Jill C GraffJodi F Hedges
Mar 6, 2007·Seminars in Nephrology·Vicki Rubin Kelley
Dec 21, 2013·PloS One·Keishi AdachiShinjiro Hamano
May 29, 2016·International Immunopharmacology·Feng QiuXiaokun Qi
Jun 1, 2005·Journal of Hepatology·Takuo InuiShuhji Seki
Oct 1, 1996·Current Biology : CB·W PaoA C Hayday
Jan 23, 2015·Innate Immunity·Jodi F HedgesMark A Jutila
Nov 22, 1997·European Journal of Immunology·B J HolmesD M Kemeny
Aug 28, 1999·International Immunology·R J Hayashi, O Kanagawa
Mar 19, 2004·Immunology·Judith A KappJeffrey P Lake
Apr 12, 2001·European Journal of Immunology·M Kawaguchi-MiyashitaM Nanno
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deborah HerberKyri Dunussi-Joannopoulos