PMID: 7540652Jul 1, 1995Paper

T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice

The Journal of Experimental Medicine
D P HughesI N Crispe

Abstract

Fas-mediated apoptosis is essential for activation-induced cell death of alpha/beta T cells, but it is not clear what role, if any, it plays in regulating other components of the immune system. To study the role of Fas in gamma/delta T cell development, Fas-deficient lpr mice were bred with T cell receptor alpha gene-ablated (TCR-alpha-/-) mice to generate mice deficient in one or both genes. The TCR-alpha-/-, lpr/lpr mice had a nearly 10-fold increase in total lymph node cell (LNC) number compared with Fas-intact TCR-alpha-/- mice, because of expansion of TCR-gamma/delta+ and TCR-beta+ cells. In Fas-intact TCR-alpha-/- mice, approximately one third of the LNCs expressed TCR-gamma/delta. These were evenly divided between the CD4-, CD8-alpha+ and the CD4-, CD8- subsets, and rarely expressed the B220 epitope of CD45. In contrast, in TCR-alpha-/-, lpr/lpr mice, TCR-gamma/delta+ cells comprised half of the LNCs and were primarily CD4-, CD8-, and B220+. Moreover, Fas deficiency in TCR-alpha-/- mice caused a preferential expansion of gamma/delta T cells expressing variable region genes characteristic of intestinal intraepithelial lymphocytes. These results demonstrate a role for Fas in regulating the gamma/delta T cell contribution t...Continue Reading

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Citations

Sep 24, 1999·Immunologic Research·I N Crispe
Dec 16, 2000·Springer Seminars in Immunopathology·C MillerA C Hayday
Jul 25, 2000·Developmental and Comparative Immunology·M D EisenbraunR A Miller
Jan 23, 1999·Current Opinion in Immunology·D M Kemeny
Sep 1, 1996·The Journal of Experimental Medicine·S L PengJ Craft
Sep 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Beverly W BaronJoseph M Baron
Dec 31, 1997·The Journal of Experimental Medicine·A MizoguchiA K Bhan
Mar 6, 2007·Seminars in Nephrology·Vicki Rubin Kelley
May 29, 2016·International Immunopharmacology·Feng QiuXiaokun Qi
Nov 22, 1997·European Journal of Immunology·B J HolmesD M Kemeny
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deborah HerberKyri Dunussi-Joannopoulos

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis