T follicular helper and TH 2 cells in allergic responses

Allergology International : Official Journal of the Japanese Society of Allergology
Masato Kubo

Abstract

IL-4 is a cytokine commonly secreted by TH2 and follicular helper T (TFH) cells after antigenic sensitization. TH2 cells have been thought to be the major contributor of B cell help as a source of IL-4 responsible for class switch recombination to Immunoglobulin G1 (IgG1) and Immunoglobulin E (IgE). Importantly, there are some differences in transcriptional regulation between these two T cell subsets. The IL-4 production by TH2 and TFHcells is distinctively regulated by two pathways, GATA-3-mediated Il4-HS2 enhancer and Notch mediated Il4-CNS-2 enhancer. IgE and IgG1 antibody responses are mainly controlled by IL-4-secreting TFHcells, but not by TH2 cells. In this review, we discuss the role of TH2 and TFHcells in IgE production and allergic responses.

Citations

Sep 10, 2017·Cellular and Molecular Life Sciences : CMLS·Kenji IzuharaTomohito Yoshihara
Jan 24, 2018·Oxidative Medicine and Cellular Longevity·Kenji IzuharaTomohito Yoshihara
Aug 5, 2018·The Journal of Biological Chemistry·Yasutaka MitamuraKenji Izuhara
Jan 23, 2020·Journal of Leukocyte Biology·Uthaman GowthamanStephanie C Eisenbarth
May 22, 2019·Immunology·Erick Esteves de OliveiraAna Paula Ferreira
Feb 18, 2020·British Journal of Haematology·Matthew CormierDavid Lillicrap
Aug 3, 2019·Science·Uthaman GowthamanStephanie C Eisenbarth
Aug 21, 2018·Current Opinion in Allergy and Clinical Immunology·Yin YaoZheng Liu
Jul 28, 2019·Nutrients·Chyn Boon WongJin-Zhong Xiao
Aug 9, 2021·Molecular Aspects of Medicine·Zsolt I KomlósiCezmi A Akdis

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