PMID: 6971106Apr 1, 1981Paper

T gamma subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis and systemic lupus erythematosus sera

Arthritis and Rheumatism
R C WilliamsJ E Levinson

Abstract

Sera from 34 patients with juvenile rheumatoid arthritis (JRA), 31 patients with systemic lupus erythematosus (SLE), and 22 normal controls were studied for microcytotoxicity before and after clearing in the ultracentrifuge. Normal T cells as well as T gamma and non-T gamma subpopulations were used. Before ultracentrifugation all test sera showed apparent T gamma cell specificity in the microcytotoxicity assay where rabbit complement was added. JRA and SLE sera produced much higher proportions of cell killing than normal controls. Ultracentrifugal clearing resulted in marked diminution in microcytotoxicity of JRA and some SLE sera. However, a considerable proportion of lupus sera continued to show T cell subset cytotoxicity after ultracentrifugal clearing. No evidence for significant alteration of T gamma rosetting capacity was recorded when ultracentrifuge-cleared test sera were preincubated with T cells prior to T gamma EA rosette formation. Apparent T gamma cytotoxic specificity in some uncleared JRA and SLE sera may relate to high molecular weight materials (IgM and immune complexes) present in such samples, whereas in others it relates to lymphocyte reactive antibody with subset reactivity.

References

Nov 1, 1979·The Journal of Experimental Medicine·J S GoodwinR C Williams
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A J StrelkauskasS F Schlossman
Dec 1, 1978·The Journal of Clinical Investigation·D Alarcón-Segovia, A Ruíz-Argüelles
May 1, 1979·European Journal of Immunology·M F GreavesA Hayward
Jan 1, 1979·Arthritis and Rheumatism·M E Hamilton, J B Winfield
Mar 8, 1979·The New England Journal of Medicine·M M FrankP H Plotz
Dec 11, 1975·The Journal of Clinical Investigation·A D Bankhurst, R C Williams
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari
Apr 1, 1980·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Dec 5, 1964·Nature·P I TERASAKI, J D MCCLELLAND

❮ Previous
Next ❯

Citations

Mar 1, 1984·Journal of Clinical Immunology·R C WilliamsT J Spira
Jul 1, 1989·Journal of Clinical Pathology·M L Biondi, B Marasini
Jan 1, 1982·The Journal of Clinical Investigation·K OkudairaR C Williams
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·A Martini
Jul 1, 1982·Arthritis and Rheumatism·R J DeHoratius
Nov 1, 1984·Arthritis and Rheumatism·K S BarronW T Shearer
Dec 1, 1987·Clinical Immunology and Immunopathology·B S EdwardsC L Hoffman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.