PMID: 7515023Jun 1, 1994Paper

T-helper- and accessory-cell-independent cytotoxic responses to human tumor cells transfected with a B7 retroviral vector

International Journal of Cancer. Journal International Du Cancer
C DöhringA Lanzavecchia

Abstract

As a means to increase the immunogenicity of tumor cells, we have developed a retroviral vector to transfect human B7, a molecule capable of delivering co-stimulatory signals to T cells. Three different tumors, a melanoma, an ovarian carcinoma and a myelomonocytic leukemia, were transfected with high efficiency. When compared for their capacity to stimulate allogeneic T cells, B7+ but not B7- tumor cells were able to stimulate strong proliferative and cytotoxic responses. The effector CTL generated recognised B7+ and B7- cells as well as untransfected tumor cells, indicating that B7 is required in the inductive but not the effector phase of the response. Remarkably, B7+ tumor cells were able to induce cytotoxic responses both by CD4-depleted and by CD8-purified T cells, demonstrating that expression of B7 is at the same time necessary and sufficient to induce a cytotoxic response in the absence of T-helper cells and accessory cells.

References

Jul 14, 1977·Nature·S Gillis, K A Smith
Jul 1, 1977·European Journal of Immunology·H von BoehmerW Haas
Dec 1, 1992·European Journal of Immunology·M de BoerJ Reeder
Apr 1, 1991·Trends in Biotechnology·A TrauneckerK Karjalainen
Oct 1, 1992·Current Opinion in Immunology·P van der Bruggen, B Van den Eynde
Jun 15, 1990·Science·R H Schwartz
Dec 1, 1985·The Journal of Experimental Medicine·J Sprent, M Schaefer
Jul 1, 1987·The Journal of Experimental Medicine·K InabaR M Steinman
Jan 1, 1987·European Journal of Immunology·A Lanzavecchia, D Scheidegger
Jan 1, 1984·The Journal of Experimental Medicine·D RamarliA Lanzavecchia
Mar 1, 1982·The Journal of Experimental Medicine·J A Keene, J Forman
Jun 1, 1993·The Journal of Experimental Medicine·F A Harding, J P Allison
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S BaskarL H Glimcher
Jan 1, 1993·Annual Review of Immunology·P S Linsley, J A Ledbetter
Jan 1, 1993·Immunology Today·B ArnoldG J Hämmerling

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Citations

Sep 1, 1996·Cancer Metastasis Reviews·P F Searle, L S Young
Mar 24, 2005·Cancer Metastasis Reviews·Kevin J HarringtonHardev S Pandha
Jun 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F AloisiG Levi
Dec 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A HabichtU Moebius
Jun 26, 2001·Respirology : Official Journal of the Asian Pacific Society of Respirology·S I IwakamiY Fukuchi
Dec 7, 2005·The Journal of Experimental Medicine·Kang LiuRalph M Steinman
Feb 27, 1999·Human Gene Therapy·J SchultzK Moelling
May 1, 2002·Transplantation·Maria Pia PistilloGiovanni Battista Ferrara
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·J Nemunaitis, J O'Brien
Jul 16, 2008·Expert Opinion on Therapeutic Targets·Manzoor A Mir, Javed N Agrewala
Mar 14, 2002·Expert Opinion on Biological Therapy·John Nemunaitis, John O'Brien
Jul 28, 1995·International Journal of Cancer. Journal International Du Cancer·R W DenfeldJ C Simon
Nov 27, 1995·International Journal of Cancer. Journal International Du Cancer·C RadmayrM Thurnher
May 19, 2009·Advanced Drug Delivery Reviews·Memy H HassanAyman Al-Hendy
Apr 29, 2008·Cancer Letters·Chulso MoonSaechul Kim
Sep 8, 2001·The Journal of Urology·K J HarringtonR G Vile
Jul 31, 1998·Hematology/oncology Clinics of North America·R Gutzmer, D Guerry
Jun 18, 2002·Seminars in Oncology·Francine M Foss
Mar 15, 2006·Vaccine·Tom A BarrAndrew W Heath
Apr 11, 2006·Human Reproduction Update·Ayman Al-Hendy, Salama Salama

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