T-helper 1 cells elicited by H5N1 vaccination predict seroprotection

The Journal of Infectious Diseases
Gabriel Kristian PedersenRebecca J Cox

Abstract

Vaccination is the best measure to protect the population against a potential influenza H5N1 pandemic, but 2 doses of vaccine are needed to elicit protective immune responses. An immunological marker for H5N1 vaccine effectiveness is needed for early identification of the best vaccine candidate. We conducted a phase I clinical trial of a virosomal H5N1 vaccine adjuvanted with Matrix M. Sixty adult volunteers were vaccinated intramuscularly with 2 doses of either 30 μg hemagglutinin (HA) alone or with 1.5, 7.5, or 30 μg HA and Matrix M adjuvant (50 μg). The humoral response was measured by the hemagglutination inhibition (HI), microneutralization (MN), and single radial hemolysis (SRH) assays, and the CD4(+) T-helper 1 (Th1)-cell response was measured by intracellular staining for the cytokines interleukin 2, interferon γ, and tumor necrosis factor α. The adjuvanted vaccine effectively induced CD4(+) Th1-cell responses, and the frequency of influenza-specific Th1 cells after the first vaccine dose predicted subsequent HI, MN, and SRH seroprotective responses after the second vaccination. These results support early identification of Th1-cell responses as a predictive biomarker for an efficient vaccine response, which could have ...Continue Reading

Associated Clinical Trials

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Citations

May 28, 2013·Archivum Immunologiae Et Therapiae Experimentalis·K Kai McKinstryTara M Strutt
Feb 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stanley A Plotkin
Sep 13, 2012·The Journal of Infectious Diseases·Rishi Delan PathiranaRebecca Jane Cox
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Cécile van ElsFredrik Oftung
Apr 16, 2015·Human Vaccines & Immunotherapeutics·Nagendra R Hegde
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Gabriel K PedersenRebecca J Cox
Jan 8, 2013·Human Vaccines & Immunotherapeutics·Rebecca J Cox
Nov 27, 2014·The Journal of Infectious Diseases·Kristin G-I MohnRebecca J Cox
Nov 8, 2014·The Journal of Infectious Diseases·Jennifer L NayakAndrea J Sant
Apr 9, 2013·Expert Review of Vaccines·P Noel BarrettHartmut J Ehrlich
Sep 1, 2015·AIDS Research and Human Retroviruses·Adriana WeinbergUNKNOWN P1086 Study Team
Apr 18, 2014·Clinical and Vaccine Immunology : CVI·Maikel V W van der VeldenGerald Aichinger
Jul 16, 2014·Expert Review of Vaccines·Brendon Y ChuaDavid C Jackson
Oct 29, 2013·Expert Review of Vaccines·Florian Krammer, Rebecca J Cox
Oct 4, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kylie M QuinnRobert A Seder
Aug 30, 2013·Expert Review of Vaccines·Karin Lövgren BengtssonLinda Stertman
Dec 10, 2014·Expert Review of Vaccines·Vidadi YusibovStephen J Streatfield
Jun 9, 2021·Expert Review of Vaccines·Xinyuan ZhangQinjian Zhao

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