T-helper 1 dominated responses to erythrocyte Band 3 in NZB mice

Immunology
C-R ShenC J Elson

Abstract

Band 3, the red blood cell (RBC) anion channel protein, is the target autoantigen for the pathogenic RBC autoantibodies and T-helper (Th) cells in New Zealand Black (NZB) mice with autoimmune haemolytic anaemia (AIHA). To determine the subpopulation of these Th cells, they were stimulated with Band 3 and the profile of the cytokines elaborated by the responding cells was measured. NZB T cells stimulated with Band 3 produced high levels of the Th1 cytokine, interferon-gamma (IFN-gamma), but little or no interleukin-4 (IL-4), IL-5 or IL-10. Similar patterns were produced by NZB T cells responding to a spectrin preparation from the RBC membrane skeleton, or to mycobacterial heat-shock protein (hsp) 65 following immunization of mice with hsp 65 in incomplete adjuvant. By contrast, T cells from CBA mice similarly immunized with hsp 65 produced high levels of IL-4 and IL-5 in response to hsp 65. Examination of the isotype of the RBC-bound immunoglobulins in NZB mice revealed that immunoglobulin G2a (IgG2a) autoantibodies were the first to be detected in most mice and that later in the disease, IgG3 autoantibodies were often prominent. It is concluded that, contrary to expectation, the development of RBC autoantibodies in NZB mice is ...Continue Reading

References

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Citations

Oct 3, 1999·Veterinary Immunology and Immunopathology·M J Day
Jul 27, 2010·Transfusion Medicine Reviews·Melca M O BarrosJosé O Bordin
Dec 1, 2006·Immunology Letters·Robert N BarkerFrank J Ward
Dec 23, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J E WitherL A Brennan
Dec 1, 2017·Frontiers in Immunology·Wei-Cheng YangChia-Rui Shen
Aug 30, 2005·Annals of the New York Academy of Sciences·Caterina Toriani-Terenzi, Enzo Fagiolo
Feb 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shimpei KasagiShunichi Kumagai

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