T helper 17 T cells do good for cancer immunotherapy

Immunotherapy
Glenda Canderan, Paolo Dellabona

Abstract

Evaluation of: Martin-Orozco N, Muranski P, Chung Y et al.: T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31(5), 787-798 (2009). The immune system plays an important role in tumor control. Tumor antigen-specific CD4(+) and CD8(+) T cells are being actively exploited in cancer immunotherapy protocols that often attain clinical responses. The T helper (Th)1 effector cytokine profile, epitomized by the production of IFN-gamma, is considered the optimal pathway in controlling tumor growth. In this study, Martin-Orozco challenges this notion by demonstrating that newly defined Th17 effector T cells display a stronger anti-tumor effect vis a vis with Th1 cells. Th17 cells produce the strongly inflammatory cytokines IL-17A and IL-17F, and so far have been implicated in the response to infectious pathogens and in autoimmunity. This study reveals that Th17 cells protect against cancer, not only by triggering a potent nonantigen-specific intratumor inflammatory infiltrate, but also, and remarkably, by providing a more significant help than Th1 cells for the efficient induction, expansion, differentiation and tumor homing of tumor-specific CD8(+) T cells. This study, therefore, sheds new light on the ef...Continue Reading

References

Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susumu NakaeYoichiro Iwakura
Oct 16, 2004·Immunity·Jay K Kolls, Anders Lindén
Mar 21, 2008·Blood·Pawel MuranskiNicholas P Restifo
Jul 2, 2008·The Journal of Experimental Medicine·Cindy S MaMatthew C Cook
Aug 30, 2008·Blood·Jinfang Zhu, William E Paul

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Citations

Sep 17, 2011·Clinical & Developmental Immunology·Shigeo KoidoHisao Tajiri
Nov 16, 2010·Seminars in Oncology·Margaret K CallahanJames P Allison
Jan 23, 2019·Frontiers in Pharmacology·Kaja KaraśMarcin Ratajewski
Nov 21, 2019·International Journal of Molecular Sciences·Kaja KaraśMarcin Ratajewski

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Methods Mentioned

BETA
transgenic

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