T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice

Gastroenterology
Elizabeth ForbesS P Hogan

Abstract

Eosinophil-associated gastrointestinal diseases are frequently associated with extraintestinal features, including bronchopulmonary manifestations. The factors predisposing to bronchial hyperresponsiveness in eosinophil-associated gastrointestinal diseases are unknown. To elucidate the mechanistic link between eosinophil-associated gastrointestinal diseases and bronchial hyperresponsiveness, we used murine models of eosinophil-associated gastrointestinal diseases and eotaxin-1/transgene-induced eosinophil-associated gastrointestinal diseases. Mice were sensitized and orally challenged with ovalbumin-coated encapsulated particles to induce eosinophil-associated gastrointestinal disease, and bronchial responsiveness was examined. Furthermore, transgenic mice expressing eotaxin in the intestine (with the rat fatty acid-binding promoter) were used to specifically elucidate the contribution of this chemokine in eosinophil-associated gastrointestinal disease-associated bronchial hyperresponsiveness. The induction of allergen-induced eosinophil-associated gastrointestinal disease was directly correlated with the development of bronchial hyperresponsiveness. The development of bronchial hyperresponsiveness in mice with allergen-induced...Continue Reading

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Citations

Apr 2, 2008·The Journal of Experimental Medicine·Elizabeth E ForbesSimon P Hogan
Mar 23, 2006·Annual Review of Immunology·Marc E Rothenberg, Simon P Hogan
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Feb 20, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiang ZhuNives Zimmermann
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard AhrensSimon P Hogan

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