T helper cells from aggressive periodontitis patients produce higher levels of interleukin-1 beta and interleukin-6 in interaction with Porphyromonas gingivalis

Clinical Oral Investigations
J R GonzalesJörg Meyle

Abstract

In this study, we analyzed the production of Interleukin-1 beta (IL-1β) and IL-6 by activated CD4+ cells obtained from aggressive periodontitis (AgP) patients in comparison with healthy subjects (HC). CD4+ cells were automatically separated from lymphocytes obtained from peripheral blood of patients with AgP and healthy controls. Cells were activated for 4, 8, and 24 h with three different stimuli: anti-CD3/anti-CD28, phytohemagglutinin (PHA), and Porphyromonas gingivalis (P. gingivalis) outer membrane protein (OMP). Protein levels were measured in supernatants of activated CD4+ cells by a bead-based immunoassay (CBA). In addition, serum antibodies against P. gingivalis were determined. Data were analyzed using U test (p < 0.05). T helper cells of AgP patients activated with P. gingivalis OMP produced higher levels of IL-1β and IL-6 in comparison with healthy controls (p < 0.05). Neither the activation with anti-CD3/anti-CD28 nor the activation with PHA showed significantly different production of IL-1β and IL-6 by the cells 25 % of patients and 17 % of controls presented with high serum reactivity to P. gingivalis. In view of these results, it is possible to conclude that P. gingivalis contributes to the pathogenesis of AgP by...Continue Reading

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Citations

Feb 24, 2016·Frontiers in Microbiology·Kah Yan HowKok Gan Chan
Aug 8, 2015·Periodontology 2000·José R Gonzales
Apr 5, 2015·Journal of Dental Research·S-J JanketJ H Meurman
Jan 12, 2020·Current Topics in Medicinal Chemistry·Abhishek WadhawanTeodor T Postolache
Sep 22, 2019·International Journal of Molecular Sciences·Rafael Scaf de MolonMarije I Koenders
Jul 8, 2019·Brain, Behavior, and Immunity·Rachel Pei-Hsuan WangRaymond Chuen-Chung Chang

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