PMID: 7542826Apr 1, 1995Paper

T-helper epitopes of the E7 transforming protein of cervical cancer associated human papillomavirus type 18 (HPV18)

Virus Research
Germain J P FernandoIan H Frazer

Abstract

The presence of T-helper epitopes within the E7 transforming protein of human papillomavirus type 18 (HPV18) was sought using a series of overlapping synthetic 15-20 mer peptides spanning the entire 105 amino acid sequence of this protein. Two H-2k restricted T-helper epitopes were defined, comprising 44VNHQHLPARRA55 and 81DDLRAFQQLF90 as the minimal T proliferative epitopes. Peptides containing these epitopes were able to provide cognate help to B epitopes from HPV18E7 protein for production of antibody to this protein in vivo in CBA/CaH mice. No H-2b or H-2d restricted epitopes were demonstrable, and in H-2d mice this was associated with poor antibody response to the E7 protein. There is no "promiscuous" T-helper epitope in HPV18 E7 comparable to the 49DRAHYNI55 sequence in HPV16 E7, and restricted T-helper epitope availability may be a determinant of poor immune responses to this protein after natural infection.

References

Jun 1, 1990·The Journal of General Virology·R W TindleI H Frazer
Feb 1, 1994·Current Opinion in Immunology·O Rötzschke, K Falk

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Citations

Oct 1, 1998·European Journal of Immunology·I H FrazerR W Tindle
Aug 19, 2004·Vaccine·Trina J StewartGermain J P Fernando
Jul 17, 2019·Papillomavirus Research·Ian H Frazer, Janin Chandra

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