T-kininogen gene expression is induced during aging.

Molecular and Cellular Biology
F SierraY Guigoz

Abstract

We have constructed a cDNA library from senescent (24-month-old) rat liver mRNA and, by differential screening, have selected clones corresponding to mRNA species with increased abundance in aging rats. Direct sequencing of the inserts indicated that most of the clones (9 of 10) contained sequences coding for T-kininogen, also called major acute-phase protein, cysteine protease inhibitor, or thiostatin. Nuclear elongation experiments showed that the increase in mRNA concentration was controlled at the transcriptional level. RNase mapping and S1 analysis indicated that the age-dependent induction operated preferentially at one of the three transcriptional start sites of the gene(s). The acute-phase reaction (inflammation) is known to also induce these genes at the level of transcription; however, two of the three start sites are induced by inflammation. Transcription from one of these sites was induced by both phenomena, aging and inflammation.

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G K McMaster, G G Carmichael
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T D SargentJ Bonner
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T Ono, R G Cutler
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 31, 1985·Biochemical and Biophysical Research Communications·T ColeG Schreiber
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A B KulkarniP Feigelson
Jan 1, 1985·Molecular Aspects of Medicine·A K Roy, B Chatterjee
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E FlemingK G Bensch
Jun 1, 1987·Nature·K A WarehamE D Williams
Jul 20, 1987·Journal of Molecular Biology·M Gardiner-Garden, M Frommer
Sep 19, 1970·Nature·H Gershon, D Gershon
Mar 1, 1984·Mechanisms of Ageing and Development·G C Webster, S L Webster
Sep 5, 1980·Journal of Molecular Biology·U SchiblerP K Wellauer
Sep 1, 1984·Archives of Biochemistry and Biophysics·K P AndersonE C Heath
Jan 1, 1981·Annual Review of Biochemistry·R Breathnach, P Chambon
Jan 1, 1982·Annals of the New York Academy of Sciences·I Kushner

❮ Previous
Next ❯

Citations

Sep 26, 2001·Experimental Cell Research·C TorresF Sierra
Jan 1, 1992·Journal of the American Geriatrics Society·R D RossI Kushner
Mar 2, 1999·Developmental Biology·V King, J Tower
Mar 30, 2010·Biochimie·Gilles LalmanachHans Fritz
Aug 30, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Viviana PérezFelipe Sierra
Jul 28, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Claudio Acuña-CastilloFelipe Sierra
Jan 8, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christian R GomezFelipe Sierra
Jun 4, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Daniel KepplerAthena W Lin
Feb 1, 1997·Journal of Molecular Neuroscience : MN·H C Wu, E H Lee
Jul 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B H BowmanG S Adrian
May 25, 2006·Shock·Christian R GomezElizabeth J Kovacs
Jan 1, 1991·Annals of the New York Academy of Sciences·D J PostJ Papaconstantinou
Oct 1, 1994·European Journal of Biochemistry·R AmmendolaF Cimino
Oct 6, 2010·Marine Biotechnology·Il-Hwa HongKyu-Shik Jeong
Apr 15, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·P RaymondA Adam
Nov 21, 1992·Annals of the New York Academy of Sciences·F SierraY Guigoz
Jan 12, 1999·Mechanisms of Ageing and Development·R WalterF Sierra
Feb 25, 2000·Brain Research. Molecular Brain Research·H HungE H Lee
Oct 13, 1995·Mechanisms of Ageing and Development·F Sierra
Aug 5, 1998·Biochimica Et Biophysica Acta·J P RabekJ Papaconstantinou
Nov 1, 1993·Molecular and Cellular Biology·H M Chen, W S Liao
Mar 1, 1991·Archives of Gerontology and Geriatrics·K Kitani
Nov 1, 1990·Mechanisms of Ageing and Development·F M YangB H Bowman
Jan 1, 1993·Mechanisms of Ageing and Development·M K ThakurY Natori
Jan 31, 1991·Biochemical and Biophysical Research Communications·E A Mann, J B Lingrel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.