T lymphocyte activation through the C28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506.

Immunology Letters
J E Kay, C R Benzie

Abstract

Nanomolar concentrations of the novel immunosuppressive drug FK-506 inhibit the proliferation of human T lymphocytes in vitro induced by mitogenic lectins or by monoclonal antibodies directed against the CD3 or CD2 surface antigens. However, the alternative pathway of T lymphocyte proliferation induced by monoclonal antibodies specific for CD28 together with phorbol esters is unaffected by FK-506.

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