PMID: 8589918Oct 1, 1995Paper

T lymphocyte chemotaxis and skin diseases

Experimental Dermatology
J Tan, K Thestrup-Pedersen

Abstract

Recent advances in our understanding of the mechanisms of T lymphocyte motility and chemotaxis, particularly in aspects of lymphocyte-endothelial adhesion, transendothelial cell migration, and T-lymphocyte response to chemotactic gradients have contributed to our knowledge of how T lymphocytes accumulate during the initiation, the development and the control of inflammatory skin responses. In this review, we will summarize the present situation of studies on T lymphocyte adhesion and chemotaxis. The 3 major steps in T lymphocyte chemotaxis, e.g., recognition of extracellular chemotactic gradients, transduction into appropriate intracellular signals, and generation of motion, will be outlined. Skin-homing T lymphocytes, chemokines and other chemoattractants will also be discussed in relation to skin diseases.

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Citations

Jun 22, 2005·Current Allergy and Asthma Reports·Andor Pivarcsi, Bernhard Homey
Mar 21, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Bruce E EllerinJoseph T Martins

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