PMID: 6169175Sep 1, 1981Paper

T lymphocyte clones having defined immunological functions

Transplantation
F W Fitch

Abstract

T cell clones are proving to be useful for analysis of various immunological phenomena. Although some clones grow well in IL 2-containing CM alone, the combination of antigen, "filler" cells, and CM improves cloning efficiency and may favor the retention of stable clones expressing a "normal" phenotype. The antigen recognition repertoire of T cells appears to be much larger than was predicted using conventional approaches. CTLs can react with at least 23 different determinants on the H-2Kb molecule of the MHC. CTLs demonstrate MHC-restricted recognition of viral and haptenic determinants, but the restriction is not strict for all cloned cells, and a variety of reactivity patterns are found. Antigen-responsive cloned T cells appear to recognize antigens in association with alloantigens encoded by the I-A region of the MHC. However, the relevant structures formed in hybrid animals include all possible combinations of peptides including those formed by trans-complementation of I-A and I-E region gene products. Culture supernatants from antigen-responsive cloned T cells contain a variety of biological activities including IL 2, B cell-stimulating factor, colony-stimulating factor, migration inhibition factor, interferon, and factor...Continue Reading

Citations

Sep 1, 1984·Veterinary Immunology and Immunopathology·M Miller-Edge, G A Splitter
Jan 1, 1984·Human Immunology·R B Effros, R L Walford
Jan 1, 1987·Experimental Gerontology·R B Effros, R L Walford
Jan 1, 1983·The Journal of Experimental Medicine·E Rothenberg, D Triglia
Apr 1, 1987·Annals of Neurology·J D PollardJ G McLeod
Jan 1, 1993·Critical Reviews in Microbiology·F M Collins

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