T-lymphocyte-fibroblast interactions

Biochemical Society Transactions
J G CrowstonA N Akbar

Abstract

At the end of the immune response, activated T-cells are cleared by apoptosis. T-cell apoptosis induced by cytokine deprivation can be inhibited by the addition of exogenous cytokines or by a fibroblast-derived survival factor. Under normal circumstances, fibroblast-mediated T-cell survival may allow persistence of a small number of primed T-cells in tissues, which can be reactivated to initiate a secondary immune response. In abnormal situations, fibroblast-mediated T-cell survival may lead to the persistence of large numbers of T-cells producing a chronic inflammatory state. Evidence derived from wound healing suggests that a bidirectional interaction is possible, and T-cells are also capable of regulating fibroblast behaviour. Persistent T-cells in the wound site thus prolong a scarring response. Potential manipulation of these interactions would provide a novel strategy for developing new therapeutic interventions. For example, administration of the fibroblast survival factor that inhibits T-cell apoptosis may prolong lymphocyte survival in lymphopenic states such as AIDS. Inhibition of the survival factor on the other hand not only has potential in the treatment of chronic inflammatory states, but may also be of value in r...Continue Reading

Citations

May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Jul 19, 2002·ANZ Journal of Surgery·Matthew P ChircopWilliam R Walsh
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tianqian ZhangDorothee Herlyn
Jun 10, 2003·The Journal of Comparative Neurology·Julie M SrogaPhillip G Popovich
Jun 20, 2006·Cancer Immunology, Immunotherapy : CII·Klara BerencsiDorothee Herlyn
Jul 17, 1999·The American Journal of Physiology·D W PowellA B West
Mar 26, 1999·European Journal of Immunology·D PillingM Salmon
Jan 27, 2004·The American Journal of Pathology·Stephan SegererHermann-Josef Gröne
Apr 20, 2001·Burns : Journal of the International Society for Burn Injuries·F RenòM Cannas
Oct 3, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Jessica A Manuel, Barbara Gawronska-Kozak
Apr 1, 2011·Journal of Translational Medicine·Klara BerencsiRajasekharan Somasundaram

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis