PMID: 1085329Aug 1, 1976

T-Lymphocyte precursors. I. Synergy between precursor and mature T lymphocytes in the response to concanavalin A

The Journal of Experimental Medicine
J J Cohen, S S Fairchild

Abstract

When mouse bone marrow cells are mixed with cortisol-resistant thymocytes and stimulated in vitro with concanavalin A, the mitogenic response observed is much greater than additive, that is, it is synergistic. Between 94 and 96% of responding cells could be identified as T cells (Thy-1 positive) and of these, 79-100% derived from the cortisol-resistant thymocyte population, not from the bone marrow. Purified macrophages could not replace bone marrow; and marrow depleted of mature T or B cells worked as well as normal marrow. Thus, T and B cells and macrophages were ruled out as the synergizing cell of bone marrow. Nude spleen contained 10 times as many precursors of T cells as did nude marrow and was 10 times better at synergy with cortisol-resistant thymocytes. This implication of the pre-T cell as synergizer was supported by the finding that the synergistic activity of marrow was lost on preincubation, but maintained if the preincubation medium contained thymosin or cyclic AMP. Thus, the ability to enhance the response of relatively mature T cells to Con A is a property of pre-T cells. It is anticipated that this property will allow more detailed studies of T-cell precursor development in mice, and possibly in man.

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M A GordonI B Wilson
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J J Cohen, S S Fairchild
Jan 1, 1978·Scandinavian Journal of Immunology·U PerssonC I Smith
Jan 1, 1977·Immunological Reviews·R G MillerR A Phillips
Jan 1, 1979·Leukemia Research·S S Fairchild, J J Cohen
Jan 1, 1988·Leukemia Research·A ImaizumiE Kimoto
Jan 1, 1984·Cellular Immunology·P R Morrow, H Abplanalp
Sep 10, 1981·Nature·F Lepault, I L Weissman
Jan 1, 1980·Journal of Supramolecular Structure·B R Acuff, J J Cohen
Jul 1, 1977·European Journal of Immunology·J A Frelinger

Citations

Oct 1, 1973·The Journal of Experimental Medicine·M P ScheidA L Goldstein
Jan 18, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L W Coppleson, D Michie
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·L N CantorR A Rifkind
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Sep 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A L GoldsteinA White

Related Concepts

Precursor Cells, T-Lymphoid
T-Lymphocyte
Spleen
Hepatitis A
Bone Marrow
Lymphoid Cells
Thymocyte
Cyclic AMP
Cell Differentiation Process
B-Lymphocytes

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.