PMID: 1085329Aug 1, 1976

T-Lymphocyte precursors. I. Synergy between precursor and mature T lymphocytes in the response to concanavalin A

The Journal of Experimental Medicine
J J Cohen, S S Fairchild


When mouse bone marrow cells are mixed with cortisol-resistant thymocytes and stimulated in vitro with concanavalin A, the mitogenic response observed is much greater than additive, that is, it is synergistic. Between 94 and 96% of responding cells could be identified as T cells (Thy-1 positive) and of these, 79-100% derived from the cortisol-resistant thymocyte population, not from the bone marrow. Purified macrophages could not replace bone marrow; and marrow depleted of mature T or B cells worked as well as normal marrow. Thus, T and B cells and macrophages were ruled out as the synergizing cell of bone marrow. Nude spleen contained 10 times as many precursors of T cells as did nude marrow and was 10 times better at synergy with cortisol-resistant thymocytes. This implication of the pre-T cell as synergizer was supported by the finding that the synergistic activity of marrow was lost on preincubation, but maintained if the preincubation medium contained thymosin or cyclic AMP. Thus, the ability to enhance the response of relatively mature T cells to Con A is a property of pre-T cells. It is anticipated that this property will allow more detailed studies of T-cell precursor development in mice, and possibly in man.


Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M A GordonI B Wilson
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J J Cohen, S S Fairchild
Jan 1, 1978·Scandinavian Journal of Immunology·U PerssonC I Smith
Jan 1, 1977·Immunological Reviews·R G MillerR A Phillips
Jan 1, 1979·Leukemia Research·S S Fairchild, J J Cohen
Jan 1, 1988·Leukemia Research·A ImaizumiE Kimoto
Jan 1, 1984·Cellular Immunology·P R Morrow, H Abplanalp
Sep 10, 1981·Nature·F Lepault, I L Weissman
Jan 1, 1980·Journal of Supramolecular Structure·B R Acuff, J J Cohen
Jul 1, 1977·European Journal of Immunology·J A Frelinger


Oct 1, 1973·The Journal of Experimental Medicine·M P ScheidA L Goldstein
Jan 18, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L W Coppleson, D Michie
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·L N CantorR A Rifkind
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Sep 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A L GoldsteinA White

Related Concepts

Precursor Cells, T-Lymphoid
Hepatitis A
Bone Marrow
Lymphoid Cells
Cyclic AMP
Cell Differentiation Process

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