PMID: 8988265Dec 24, 1995Paper

T-lymphocyte proliferative response to mitogen stimulation in elderly depressed patients

Journal of Affective Disorders
F BrambillaA Panerai

Abstract

T-lymphocyte responses to phytohemoagglutinin (PHA) stimulation were examined in 10 elderly women with nonmelancholic Major Depressive Disorders (MDD), in 10 age- and sex-matched controls and in 10 young female controls, before and after in vivo stimulation with corticotropin-releasing hormone (CRH). The tests were repeated in MDD patients after 30 days of therapy with phosphatidylserine (BC-PS), 200 mg/day, p.o. T-lymphocyte responses to PHA stimulation did not differ in the three groups, and were not changed by CRH administration. BC-PS therapy, while significantly improving the depressive symptomatology, did not modify the T-lymphocyte response to PHA, either before or after CRH stimulation.

References

Feb 1, 1991·Archives of General Psychiatry·M SteinR L Trestman
Mar 1, 1990·Acta Psychiatrica Scandinavica·M MaggioniF Brambilla
Apr 1, 1991·Biological Psychiatry·D RiemannM Berger
Oct 1, 1989·Biological Psychiatry·S D TargumD Martin
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Citations

May 7, 1998·Acta Psychiatrica Scandinavica·F Brambilla, M Maggioni
Oct 31, 2002·Human Psychopharmacology·Ahmed A WadeeMichael Maes

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