T lymphocyte responses to anti-neutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission

Clinical and Experimental Immunology
W J KingC O Savage

Abstract

ANCA with specificity for myeloperoxidase (MPO) and proteinase 3 (PR3) are present in patients with systemic vasculitis. The aim of this work was to determine whether such patients have T cell responses to these antigens and whether these responses are related to disease activity. Peripheral blood lymphocytes from 45 patients and 19 controls were cultured with ANCA antigens and proliferation measured. The antigens used were heat-inactivated (HI) MPO, HI PR3, native (non-HI) PR3, HI whole alpha-granules, and 25 overlapping peptides covering the entire PR3 sequence. Significant responses to both whole PR3 preparations were seen from patient and control groups, and to the alpha-granules from the patient group. Patients responded at all stages of disease: active, remitting, treated or untreated. Only two patients responded significantly to MPO. Responses were significantly higher with the patient group than the control group to all four whole ANCA antigens. Responses to those PR3 peptides containing epitopes known to be recognized by ANCA were detected from one patient. Thus, these studies demonstrate that T cells from vasculitis patients can proliferate to PR3 and occasionally to associated ANCA antigens. Further, responses may pe...Continue Reading

References

Sep 1, 1992·Clinical and Experimental Immunology·N TandonA P Weetman
May 1, 1992·Clinical Immunology and Immunopathology·P W MathiesonD B Oliveira
Dec 1, 1991·Journal of Leukocyte Biology·L A CharlesJ C Jennette
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C M DayanM Feldmann
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R J FalkJ C Jennette
Jan 1, 1990·APMIS. Supplementum·P Schollmeyer, W Grotz
Jul 26, 1990·The New England Journal of Medicine·P W MathiesonH Waldmann
Apr 1, 1987·Kidney International·D H HookeR C Atkins
Jan 1, 1968·Advances in Immunology·D W Dresser, N A Mitchison
Apr 15, 1983·Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego·B Batko
Apr 1, 1982·The Western Journal of Medicine·H FrolichK S Hansen
Jun 1, 1995·The Journal of Experimental Medicine·A Lanzavecchia
May 1, 1995·Clinical and Experimental Immunology·P W Mathieson, D B Oliveira
May 1, 1995·Clinical and Experimental Immunology·B E BallieuxM R Daha
Dec 1, 1994·Clinical and Experimental Immunology·E BrouwerC G Kallenberg
Feb 1, 1994·Arthritis and Rheumatism·J C JennetteC G Kallenberg
Jan 1, 1993·Advances in Experimental Medicine and Biology·N B AllenR M McCallum
Mar 1, 1993·Clinical and Experimental Immunology·C A StegemanC G Kallenberg
Feb 1, 1996·Clinical and Experimental Immunology·M E GriffithC D Pusey
Feb 22, 1997·Lancet·C O SavageD Adu

❮ Previous
Next ❯

Citations

Jul 4, 2003·The New England Journal of Medicine·David JayneUNKNOWN European Vasculitis Study Group
Sep 1, 2001·Clinical and Experimental Immunology·C E BaldingC O Savage
Jul 25, 2014·Seminars in Immunopathology·Eoin F McKinneyKenneth G C Smith
Oct 10, 2001·Springer Seminars in Immunopathology·M E Griffith, C D Pusey
Jun 3, 1999·Scandinavian Journal of Immunology·W J MayetK H Meyer Zum Büschenfelde
Jul 4, 2008·Kidney International·Jiajin YangGloria A Preston
Jun 9, 2000·Kidney International·C F FranssenJ W Tervaert
Apr 17, 2004·Kidney International·Wilhelm H SchmittUNKNOWN European Vasculitis Study Group
Aug 16, 2011·Seminars in Nephrology·Ruth M TarziCharles D Pusey
May 2, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marjan C SlotJan Willem Cohen Tervaert
Mar 15, 2005·Clinical and Experimental Immunology·S MarinakiF J Van Der Woude
Jul 6, 2005·Clinical and Experimental Immunology·P Lamprecht
Jul 30, 2009·APMIS. Supplementum·Peter LamprechtCees G M Kallenberg
May 30, 2009·Arthritis and Rheumatism·Annelies E BerdenIngeborg M Bajema
Jun 26, 2008·Arthritis and Rheumatism·Wayel H AbdulahadCees G M Kallenberg
Nov 29, 2001·Rheumatic Diseases Clinics of North America·L Harper, C O Savage
Jul 10, 2013·Orvosi hetilap·Klára GadóGyula Domján
Jul 26, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Gian Luca ErreGiuseppe Passiu
Feb 24, 2000·The Journal of Pathology·L Harper, C O Savage
May 6, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Stephen R Holdsworth, Poh-Yi Gan
Jun 14, 2006·Journal of the American Society of Nephrology : JASN·Amanda-Jane RuthStephen R Holdsworth
Jan 28, 2012·Journal of the American Society of Nephrology : JASN·William G Couser
Dec 2, 2005·Current Opinion in Hematology·John Barrett, Katayoun Rezvani
Jan 16, 2002·Current Opinion in Rheumatology·Caroline O S SavageMark Holland
Dec 16, 2003·Current Opinion in Rheumatology·Dennis HuugenPeter Heeringa
Oct 27, 2004·Clinical Science·Julie M WilliamsCaroline O S Savage
Apr 20, 2021·Frontiers in Immunology·Yuji Nozaki
Oct 18, 2000·Journal of Immunological Methods·Y M van der GeldC G Kallenberg
Aug 23, 2002·Journal of Immunological Methods·Y M Van der GeldC G M Kallenberg
Sep 29, 2001·Kidney International·C O Savage
Dec 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Zoltán BártfaiUlrich Specks
Dec 23, 2006·Néphrologie & thérapeutique·Vincent Louis-Marie EsnaultDominique Besnier
Oct 18, 2005·La Presse médicale·P GuilpainL Mouthon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.