T-lymphocyte sensitivity to specific antibodies in hepatitis B
Zhurnal mikrobiologii, epidemiologii, i immunobiologii
B A Gerasun, I V Danileĭchenko
The study has revealed that in cases of an extremely severe course of viral hepatitis B and in persons susceptible to the development of renal encephalopathy resistance to specific antibodies of antilymphocytic gamma-globulin develops. This is manifested by a decrease in the titer of antilymphocytic gamma-globulin in the test of the specific inhibition of E-rosette formation with the patient's lymphocytes, previously incubated with antibodies. The test is of prognostic importance and can be recommended for immunological monitoring with a view to controlling the course of the disease.
Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.