PMID: 332183Jul 1, 1977Paper

T-lymphocyte subpopulation in untreated SLE. Variations with disease activity

Arthritis and Rheumatism
S J RiveroD Alarcón-Segovia

Abstract

An active subpopulation of T lymphocytes characterized by their ability to form early rosettes with sheep erythrocytes (active E-RBL) was studied in the blood of 50 patients with untreated systemic lupus erythematosus (SLE) and in 50 normal controls. The findings were related to the absolute number of circulating lymphocytes and total E-receptor-bearing lymphocytes (total E-RBL). Lupus patients with active disease had markedly decreased absolute lymphocyte counts, but the decrease of both the total and the active E-RBL surpassed what would be expected from the lymphopenia. Patients with inactive disease had moderately decreased absolute lymphocyte counts with a marked and disproportionate decrease in total E-RBL and a moderate decrease in active E-RBL, which seemed to reflect only the absolute lymphopenia. Patients with active disease had significantly lower active E-RBL than those with inactive disease. The changes of these and other lymphocyte subpopulations in relation to disease activity in SLE may reflect the influence of factors leading to T-cell depletion and immaturity. Circulating thymic products may be one of those factors.

References

Sep 1, 1975·Clinical Immunology and Immunopathology·S HorowitzR Hong
May 1, 1976·Arthritis and Rheumatism·E C KeystoneD A Gordon
Jul 1, 1974·Arthritis and Rheumatism·P J ClementsE V Barnett
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Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen

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Citations

Apr 1, 1978·Arthritis and Rheumatism·S J RiveroD Alarcón-Segovia
May 1, 1978·Arthritis and Rheumatism·E Díaz-JouanenD Alarcón-Segovia
Jan 1, 1979·Arthritis and Rheumatism·M E Hamilton, J B Winfield
May 1, 1991·Arthritis and Rheumatism·D A FoxW J McCune
Oct 1, 1981·Journal of Clinical Immunology·G C Tsokos, J E Balow
Sep 1, 1986·Clinical Rheumatology·E PaterakiA Aessopos
Oct 1, 1982·Immunopharmacology·K NekamA J Strelkauskas
Dec 1, 1978·The Journal of Clinical Investigation·D Alarcón-Segovia, A Ruíz-Argüelles
Feb 14, 2009·Lupus·A La Cava
Apr 1, 1980·Arthritis and Rheumatism·M L BernsteinS A Dobson
Jan 18, 2011·Clinical and Experimental Immunology·D Gómez-MartínJ Alcocer-Varela
Jul 1, 1988·Arthritis and Rheumatism·M H LiangJ M Esdaile
Apr 1, 1982·Arthritis and Rheumatism·M GioudJ C Monier
Jul 1, 1983·Arthritis and Rheumatism·J RovenskýJ Lokaj

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