PMID: 6976615Jan 1, 1981Paper

T-lymphocyte subpopulations in the peripheral blood of patients with Crohn's disease

Scandinavian Journal of Gastroenterology
M PfreundschuhJ D Beck

Abstract

Samples of peripheral blood from 26 patients with Crohn's disease (CD) and 26 healthy age- and sex-matched controls were tested simultaneously for B and T lymphocytes and T-lymphocyte subpopulations with receptors for IgM (TM) and IgG (TG). Patients with CD had reduced proportions of T lymphocytes, and this reduction showed a significant correlation to the CD activity index (r = -0.65, p less than 0.01). There was slight reduction of TM only (p less than 0.05) inpatients with highly active disease but not in the total population of patients studied. Proportions of B and TG cells were similar in patients and controls. Patients with no clinical or radiological but histological signs of active disease had T lymphocytes and subpopulations like patients with inactive disease. This suggests that the reduction of T cells and T-cell subpopulations in CD are secondary effects. With regard to T-lymphocyte subpopulations, our results are in contrast to a recently published report and do not suggest that analysis of T cells according to the expression of Fc receptors helps in the understanding of functional changes in the T-cell system in patients with CD.

References

Jan 1, 1977·Immunological Reviews·H Cantor, E A Boyse
Oct 1, 1977·European Journal of Immunology·L MorettaM D Cooper
Sep 1, 1979·Arthritis and Rheumatism·G BiberfeldP Biberfeld
Jan 1, 1976·Annals of the New York Academy of Sciences·D B SacharH D Janowitz
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari
Apr 1, 1980·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Apr 1, 1980·Clinical Immunology and Immunopathology·R C WilliamsJ D Montaño

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Citations

Sep 1, 1992·Digestive Diseases and Sciences·G A NeilT J Waldschmidt
Nov 2, 1982·Klinische Wochenschrift·M PfreundschuhG E Feurle
Sep 1, 1994·Digestive Diseases and Sciences·G A NeilT J Waldschmidt
Jun 1, 1984·The Australian and New Zealand Journal of Surgery·R P LearmonthE S Hughes
Nov 1, 1983·Scandinavian Journal of Gastroenterology·F PalloneP Pozzilli

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