Dec 20, 1984

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

Nature
D KlatzmannL Montagnier

Abstract

Many viruses, including retroviruses, are characterized by their specific cell tropism. Lymphadenopathy-associated virus (LAV) is a human lymphotropic retrovirus isolated from patients with acquired immune deficiency syndrome (AIDS) or related syndromes, that displays selective tropism for a subset of T lymphocytes defined by the expression of a surface glycoprotein of relative molecular mass 62,000 (62K) termed T4 (refs 6-8). This glycoprotein delineates a subset of T lymphocytes with mainly helper/inducer functions, while T lymphocytes of the reciprocal subset express a glycoprotein termed T8, have mainly cytotoxic/suppressor activities, and are unable to replicate LAV. Such a tropism may be controlled at the genomic level by regulatory sequences, as described for the human T-cell leukaemia viruses HTLV-I and -II (refs 2, 3). Alternatively or concomitantly, productive cell infection may be controlled at the membrane level, requiring the interaction of a specific cellular receptor with the virus envelope, as demonstrated recently for Epstein-Barr virus (EBV). Therefore, we have investigated whether the T4 molecule itself is related to the receptor for LAV. We report here that preincubation of T4+ lymphocytes with three individ...Continue Reading

  • References14
  • Citations1179
  • References14
  • Citations1179

Citations

Mentioned in this Paper

Monoclonal Antibodies
T-Lymphocyte
Antigenic Specificity
Neoglycoproteins
OR1S1
Lymphatic Diseases
Receptors, Virus
Acquired Immunodeficiency Syndrome
Leukemia, T-Cell
Retroviridae Infections

About this Paper

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