PMID: 8977606Oct 1, 1996Paper

T lymphocytes and silica-induced pulmonary inflammation and fibrosis in mice

Thorax
N SuzukiK Ito

Abstract

Silica-induced pulmonary inflammation and fibrosis in animals provides a good model for chronic pulmonary inflammation and fibrosis. Although lymphocytes are implicated in the pathogenesis of pulmonary fibrosis, experimental models using silica-treated athymic nude mice have not been successful in showing the fibrogenic mechanism regulated by T cells. The aim of this study was to re-evaluate the role of T lymphocytes in the development of silicosis by comparing the response to silica administration of nude athymic mutants with that of euthymic animals. Suspensions of silica particles were transnasally administered to nude athymic mice (Balb/c nu/nu) as well as to their euthymic littermates (Balb/c nu/+). The degree of pulmonary inflammation and fibrosis was assessed on days 14, 28, and 56 based upon histological observation, analysis of collagen deposition in the lungs, and analysis of the cellular constituent, protein, and phospholipid content in the bronchoalveolar lavage fluid. Histologically, athymic mice developed less severe interstitial pneumonitis than euthymic mice. In euthymic mice the lung hydroxyproline content increased with time after silica administration from 6.48 (0.38) micrograms hydroxyproline/mg dry lung wei...Continue Reading

References

May 1, 1976·Thrombosis Research·T MaekawaT Takeuchi
Aug 1, 1992·The American Review of Respiratory Disease·H TakizawaH Okudaira
Aug 1, 1990·Immunological Investigations·R K KumarR O'Grady
Apr 1, 1990·American Journal of Respiratory Cell and Molecular Biology·R M StrieterS L Kunkel
May 6, 1989·Lancet·A O'Garra
Jan 1, 1985·The Journal of Antibiotics·H EkimotoH Umezawa
Feb 1, 1989·The American Journal of the Medical Sciences·J C Weissler
Apr 1, 1986·The Journal of Pathology·H L GritterG M King
Apr 29, 1967·Nature·A G Heppleston, J A Styles
Aug 1, 1970·The Journal of Pathology·A G HepplestonJ A Stewart
Jan 1, 1973·British Journal of Industrial Medicine·M GrünspanW Dehnen
May 1, 1983·The American Review of Respiratory Disease·G L Snider
May 1, 1983·The American Review of Respiratory Disease·D J SchrierB M McGarry
Jan 1, 1982·American Journal of Industrial Medicine·B Pernis, E C Vigliani
May 1, 1984·The American Review of Respiratory Disease·E M LuganoR P Daniele
Jan 1, 1984·Experimental Lung Research·J O CantorG M Turino
Mar 1, 1983·European Journal of Pediatrics·W KiessR Eife
Oct 1, 1982·The Journal of Clinical Investigation·P B BittermanR G Crystal
Nov 1, 1993·American Journal of Respiratory Cell and Molecular Biology·N SuzukiT Miyamoto
Feb 1, 1993·Chest·S T HolgateW Roche
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

❮ Previous
Next ❯

Citations

Oct 18, 2003·Cytokine & Growth Factor Reviews·Sergei P Atamas, Barbara White
Jul 18, 2001·The Journal of Experimental Medicine·V M BorgesG A DosReis
Apr 18, 2001·American Journal of Respiratory Cell and Molecular Biology·M ArrasD Lison
Feb 21, 2004·American Journal of Respiratory Cell and Molecular Biology·Virginie BarbarinFrançois Huaux
Jun 26, 2010·Journal of Leukocyte Biology·Celine A BeamerAndrij Holian
Jun 25, 2010·European Radiology·Xabier ArtaechevarriaCarlos Ortiz-de-Solorzano
Mar 14, 2007·Current Opinion in Allergy and Clinical Immunology·François Huaux
Oct 6, 2005·Experimental Lung Research·Thomas H ThatcherRichard K Barth
Jan 18, 2015·Toxicology and Applied Pharmacology·Yashodhar P BhandarySreerama Shetty
Apr 4, 2015·Journal of Clinical Biochemistry and Nutrition·Yasuo ShimizuTomihiro Kamiya
Apr 6, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·T BaroniG Abbritti
Jun 16, 2007·The American Journal of Pathology·Kerill PochetuhenSergei P Atamas
Oct 12, 2010·The Journal of Toxicological Sciences·Masayuki OhbayashiToshinori Yamamoto
Dec 9, 2017·American Journal of Respiratory Cell and Molecular Biology·Ke NiWenwei Tu
Sep 22, 2018·American Journal of Respiratory Cell and Molecular Biology·Naoya SugimotoKen Ohta
Sep 15, 2018·Experimental and Therapeutic Medicine·Sachiko ShioyaNoboru Hattori
Oct 27, 2007·Journal of Leukocyte Biology·Irina G LuzinaSergei P Atamas
Jul 6, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·J MorrisonG Bou-Gharios
Jun 3, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·H GarnD Gemsa
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·François HuauxSem H Phan
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takashi SatoDennis M Klinman
May 11, 2018·Environmental Health : a Global Access Science Source·Hanpeng LaiWeihong Chen
Apr 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandra Lo ReFrançois Huaux
Nov 20, 2012·Journal of Leukocyte Biology·Sandra Lo ReFrançois Huaux

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.