T lymphocytes in mercury-exposed workers

Immunopharmacology and Immunotoxicology
M L Queiroz, D C Dantas

Abstract

In this work we have investigated the changes in T-helper and T-suppressor cells and T-cell proliferative response to phytohemagglutinin (PHA) in mercury-exposed workers. The study group consisted of 33 workers from a mercury-producing plant with a mean age of 29 years and a mean exposure period of 19 months. At the time of testing, and for the three previous months, the exposed population had urinary mercury levels below the currently accepted limit of 50 micrograms/g creatinine. A reverse CD4+/CD8+ ratio was observed in the mercury-exposed individuals which was characterized by a reduction in the number of CD4+ lymphocytes. No changes were observed in the proliferative response of lymphocytes from exposed individuals to PHA. Similarly, no proliferative response was observed when lymphocytes from normal individuals were cultivated in the presence of serum from the exposed workers. We found no correlations between lymphocytes changes and urinary mercury concentrations, time of exposure or the age of the workers.

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Citations

May 1, 2001·The Science of the Total Environment·M ValentinoE Mocchegiani
Jan 7, 1999·International Journal of Immunopharmacology·A J RosenspireM J McCabe
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B WatzlB L Pool-Zobel
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Jan 26, 2012·Environmental Health Perspectives·Margaret R KaragasSusan Korrick
Nov 15, 2013·Journal of Proteome Research·Nicholas J CaruthersAllen Rosenspire
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Dec 19, 2002·Revista de saúde pública·Marcília de Araújo Medrado Faria
Jun 9, 1998·Human & Experimental Toxicology·M L QueirozS T Saad
Oct 14, 2020·Nature Immunology·Takafumi SuzukiMasayuki Yamamoto

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