PMID: 6973605Aug 1, 1981Paper

T lymphocytes specific for immunoglobulin allotype. I. Igh-1b-specific T cells demonstrated by suppression in vivo and cytotoxicity in vitro

The Journal of Experimental Medicine
H R SnodgrassM J Bosma

Abstract

We show that determinants of IgG(2a) of C57BL/6 mice (Igh-1(b)) stimulate allotypespecific T cells in BALB/c mice. Such cells are detected in two different functional assays; chronic allotype suppression and T cell-mediated cytotoxicity. A population of suppressor T cells capable of inducing chronic Igh-1(b) suppression was demonstrated by rosetting procedures to possess Igh-1(b)-specific receptors, a result interpreted as indicating that suppressor T cells may act directly upon allotype-bearing B cells. From similar populations we were also able to demonstrate Igh-1(b)-specific cytotoxic T cells. Such cells were lytic for target myeloma cells expressing the Igh-1(b) allotype of IgG28, and were ineffective against a variant cell line failing to express Igh-1(b), and other target cell lines expressing different allotypes or isotypes. The similar specificity of suppressor T cells and cytotoxic T lymphocytes for Igh-1(b) allotype raises the possibility that the target in allotype suppression is a B cell, and that allotype-specific cytotoxic T cells may play some role in regulation of allotype expression in the suppressed state.

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C A JanewayH Wigzell
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S SegalM Feldman
Oct 1, 1979·The Journal of Experimental Medicine·Y Dohi, A Nisonoff
Mar 1, 1977·The Journal of Experimental Medicine·M J Bosma, G C Bosma
Nov 1, 1977·The Journal of Experimental Medicine·M Taniguchi, J F Miller
Aug 1, 1978·European Journal of Immunology·M J BosmaJ L Owen
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Jan 1, 1975·Transplantation Reviews·T TadaT Takemori
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Aug 1, 1981·The Journal of Experimental Medicine·H R SnodgrassD B Wilson

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Citations

Mar 1, 1989·Research in Immunology·C Leclerc
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S MaekawaZ Ovary
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D S TaylorJ Kornbluth
Aug 1, 1981·The Journal of Experimental Medicine·H R SnodgrassD B Wilson
Nov 1, 1981·The Journal of Experimental Medicine·J FormanE S Vitetta
Jul 1, 1984·European Journal of Immunology·R Zamoyska, H Waldmann
Feb 1, 1987·European Journal of Immunology·P Benaroch, G Bordenave

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