T-lymphokine-activated killer cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in glioma

Oncotarget
Chuntao QuanLin Liu

Abstract

TOPK is overexpressed in various types of cancer and associated with poor outcomes in different types of cancer. In this study, we first found that the expression of T-lymphokine-activated killer cell-originated protein kinase (TOPK) was significantly higher in Grade III or Grade IV than that in Grade II in glioma (P= 0.007 andP< 0.001, respectively). Expression of TOPK was positively correlated with Ki67 (P< 0.001). Knockdown of TOPK significantly inhibited cell growth, colony formation and increased sensitivities to temozolomide (TMZ) in U-87 MG or U-251 cells, while TOPK overexpression promoted cell growth and colony formation in Hs 683 or A-172 cells. Glioma patients expressing high levels of TOPK have poor survival compared with those expressing low levels of TOPK in high-grade or low-grade gliomas (hazard ratio = 0.2995; 95% CI, 0.1262 to 0.7108;P= 0.0063 and hazard ratio = 0.1509; 95% CI, 0.05928 to 0.3842;P< 0.0001, respectively). The level of TOPK was low in TMZ-sensitive patients compared with TMZ-resistant patients (P= 0.0056). In TMZ-resistant population, patients expressing high TOPK have two months' shorter survival time than those expressing low TOPK. Our findings demonstrated that TOPK might represent as a promi...Continue Reading

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Citations

Oct 26, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Giacomo PirovanoThomas Reiner
May 18, 2020·Cancers·Madeleine EttaiebHarm Haak
Nov 18, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Giacomo PirovanoThomas Reiner
Jul 30, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Akinobu OtaYoshitaka Hosokawa

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