PMID: 8580461Oct 1, 1995Paper

T-lymphopoietic capacity of the mouse intestinal epithelium

Seminars in Immunology
J R Klein

Abstract

Small intestine intraepithelial lymphocytes (i-IELs) comprise a heterogeneous population of T cells that are part of the gut-associated lymphoid tissues. Recent studies indicate that murine i-IELs are greatly enriched for extrathymic T cells. Yet there is disagreement as to which i-IELS are extrathymic and which are not, and many aspects of intestinal T-cell development remain controversial. In this article, the developmental lineages of murine i-IELs are examined, and the thymopoietic potential of the intestine epithelium is discussed. A mechanism is described whereby all intestinal T cells develop extrathymically, and a concept of intestinal T cells is presented which suggests that lineages of i-IELs need to be viewed according to developmental factors exclusive of thymus dependency.

Citations

Dec 16, 1997·Developmental and Comparative Immunology·M HamadJ R Klein
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·C N LeveltS J Simpson
Oct 1, 1996·The Journal of Experimental Medicine·J R Klein
Feb 17, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Asa V KeitaJohan D Söderholm
Mar 14, 2014·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Koji TanabeShinya Yamanaka

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