T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking.

BMC Medical Genetics
Khaled K Abu-AmeroNduna Dzimiri

Abstract

The association of the deletion in GSTT1 and GSTM1 genes with coronary artery disease (CAD) among smokers is controversial. In addition, no such investigation has previously been conducted among Arabs. We genotyped 1054 CAD patients and 762 controls for GSTT1 and GSTM1 deletion by multiplex polymerase chain reaction. Both CAD and controls were Saudi Arabs. In the control group (n = 762), 82.3% had the T wild M wildgenotype, 9% had the Twild M null, 2.4% had the Tnull M wild and 6.3% had the Tnull M null genotype. Among the CAD group (n = 1054), 29.5% had the Twild M wild genotype, 26.6% (p < .001) had the Twild M null, 8.3% (p < .001) had the Tnull M wild and 35.6% (p < .001) had the Tnull M null genotype, indicating a significant association of the Twild M null, Tnull M wild and Tnull M null genotypes with CAD. Univariate analysis also showed that smoking, age, hypercholesterolemia and hypertriglyceridemia, diabetes mellitus, family history of CAD, hypertension and obesity are all associated with CAD, whereas gender and myocardial infarction are not. Binary logistic regression for smoking and genotypes indicated that only M null and Tnullare interacting with smoking. However, further subgroup analysis stratifying the data by s...Continue Reading

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Citations

Dec 6, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Lian-Sheng WangBin Wang
Jun 14, 2008·Journal of Hypertension·Christian DellesAnna F Dominiczak
May 22, 2013·American Journal of Hypertension·Roberto SchreiberWilson Nadruz
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Methods Mentioned

BETA
coronary artery bypass
PCR

Software Mentioned

SPSS

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