T regulatory cells: aid or hindrance in the clearance of disease?

Journal of Cellular and Molecular Medicine
Clint A ColemanIvona Pandrea

Abstract

CD4+ CD25+ T regulatory cells (Tregs) are classified as a subset of T cells whose role is the suppression and regulation of immune responses to self and non-self. Since their discovery in the early 1970s, the role of CD4+ CD25+ Tregs in both autoimmune and infectious disease has continued to expand. This review examines the recent advances on the role CD4+ CD25+ Tregs may be playing in various diseases regarding progression or protection. In addition, advances made in the purification and manipulation of CD4+ CD25+ Tregs using new cell markers, techniques and antibodies are discussed. Ultimately, an overall understanding of the exact mechanism which CD4+ CD25+ Tregs implement during disease progression will enhance our ability to manipulate CD4+ CD25+ Tregs in a clinically beneficial manner.

References

Apr 1, 1992·Immunology Today·B R BloomB Diamond
Mar 1, 1988·Scandinavian Journal of Immunology·G Möller
Jun 1, 1988·Scandinavian Journal of Immunology·C A Janeway
May 1, 1982·The Journal of Pediatrics·B R PowellP Stenzel
Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Nov 1, 1993·Immunology Today·D R Green, D R Webb
Aug 1, 1996·The Journal of Experimental Medicine·M AsanoS Sakaguchi
Apr 7, 1997·The Journal of Experimental Medicine·Y WuY Liu
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·G NocentiniC Riccardi
Sep 25, 1998·Journal of Internal Medicine·O WitzkeT Philipp
Jan 11, 2000·QJM : Monthly Journal of the Association of Physicians·F SyedJ F Morrison
Apr 19, 2000·The Journal of Experimental Medicine·B Rehermann
Jun 3, 2000·Annual Review of Immunology·E M Shevach
Jul 11, 2000·The Journal of Allergy and Clinical Immunology·M K Levings, M G Roncarolo
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F CottrezH Groux
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G J WebsterA Bertoletti
Dec 20, 2000·The Journal of Clinical Investigation·T A ChatilaA M Bowcock
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·M IwashiroK J Hasenkrug
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Baecher-AllanD A Hafler
Nov 13, 2001·American Journal of Clinical Dermatology·D P FiggittK L Goa
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cherry I KingsleyKathryn J Wood
Mar 20, 2002·Clinical Journal of Oncology Nursing·M Saxon

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Citations

Jun 23, 2009·International Immunopharmacology·Jiang LiYi-Xin Zeng
Feb 18, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Pietro PresicceClaire A Chougnet
Jan 6, 2009·Current Opinion in Psychiatry·Timothy G Dinan
Feb 21, 2018·Scientific Reports·Deepak TripathiRamakrishna Vankayalapati
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ivona PandreaCristian Apetrei
Oct 27, 2017·Annals of the American Thoracic Society·David R MollerAndrew P Fontenot

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Methods Mentioned

BETA
co-immunoprecipitation
transgenic
antibodydepletion

Software Mentioned

ONTAK
CLUSTALW

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