T-style keratoprosthesis based on surface-modified poly (2-hydroxyethyl methacrylate) hydrogel for cornea repairs

Materials Science & Engineering. C, Materials for Biological Applications
Jun XiangJianjiang Xu

Abstract

Corneal disease is a common cause of blindness, and keratoplasty is considered as an effective treatment method. However, there is a severe shortage of donor corneas worldwide. This paper presents a novel T-style design of a keratoprosthesis and its preparation methods, in which a mechanically and structurally effective artificial cornea is made based on a poly(2-hydroxyethyl methacrylate) hydrogel. The porous skirt was modified with hyaluronic acid and cationized gelatin, and the bottom of the optical column was coated with poly(ethylene glycol). The physical properties of the T-style Kpro were analyzed using ultraviolet and visible spectrophotometry and electron scanning microscopy. The surface chemical properties were characterized using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The surface modification in the spongy skirt promoted cell adhesion and produced a firm bond between the corneal tissue and the implant device, while the surface modification in the optic column resisted cell adhesion and prevented retroprosthetic membrane formation. Through improved surgical techniques, the novel T-style keratoprosthesis provides enough mechanical stability to facilitate long-term biointegration w...Continue Reading

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Citations

May 22, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Zhaoxing DaiXinghuai Sun
Feb 16, 2017·ACS Applied Materials & Interfaces·Jianguo SunXinghuai Sun
Oct 21, 2016·Macromolecular Bioscience·Heidi StollMeltem Avci-Adali
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tugce A AricaMustafa M Demir
Apr 23, 2021·Small·Sadjad KhosravimelalMazaher Gholipourmalekabadi
Mar 30, 2019·ACS Applied Materials & Interfaces·Jeffrey W ChenJeffrey Schwartz

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