T-T cell interactions during cytotoxic T cell responses. IV. Murine lymphoid dendritic cells are powerful stimulators for helper T lymphocytes

European Journal of Immunology
M RöllinghoffH Wagner

Abstract

Enriched populations of Ia+ Fc receptor-negative dendritic cells were compared to other cell types for their stimulatory activity in primary mixed lymphocyte reactions to alloantigens and 2,4,6,-trinitrophenylated syngeneic cells. Dendritic cells were 20-100 times more effective than unfractionated splenocytes. A second cell type exhibiting strong stimulatory activity was an Ia+ Fc receptor-positive transiently adherent cell. Both types of stimulatory cells were only effective when able to produce the monokine interleukin 1. Thus glutaraldehyde-fixed cells were not stimulatory unless extraneous interleukin 1 was added. Stimulation of helper cells by either dendritic cells or Ia+ Fc receptor-positive cells resulted in the production of interleukin 2. The data are discussed in view of the recently formulated interleukin model as a minimal scheme to explain T-T cell interactions during the in vitro induction of cytotoxic T lymphocytes.

References

Jun 1, 1975·The Journal of Allergy and Clinical Immunology·D W Talmage, H Hemmingsen
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R M Steinman, M D Witmer
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Feb 1, 1974·The Journal of Experimental Medicine·R M Steinman, Z A Cohn
Jul 29, 1966·Science·F H Bach, N K Voynow
Jan 1, 1980·Immunological Reviews·R M Steinman, M C Nussenzweig
Jun 1, 1980·The Journal of Experimental Medicine·K A SmithM F Favata
Oct 1, 1980·The Journal of Experimental Medicine·M C NussenzweigZ A Cohn
Jan 1, 1980·Immunological Reviews·K A Smith

❮ Previous
Next ❯

Citations

Sep 1, 1991·Transplant International : Official Journal of the European Society for Organ Transplantation·W MoolenaarF J van der Woude
Aug 3, 1984·Journal of Immunological Methods·M L KapsenbergP J Roholl
Nov 1, 1989·Research in Immunology·C J Melief
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M Francotte, J Urbain
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S Koide, R M Steinman
Feb 1, 1983·The Journal of Experimental Medicine·R M SteinmanM C Nussenzweig
Dec 1, 1984·Immunobiology·K C Lee, C Guidos
Jun 2, 1983·Nature·A N Barclay, D W Mason
Dec 1, 1983·European Journal of Immunology·H Miyazaki, T Osawa
Jan 1, 1990·International Reviews of Immunology·K InabaR M Steinman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.