T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy

Kidney International
N SuganoK Hayashi

Abstract

T-type calcium channel blockers have been previously shown to protect glomeruli from hypertension by regulating renal arteriolar tone. To examine whether blockade of these channels has a role in protection against tubulointerstitial damage, we used a stereo-selective T-type calcium channel blocker R(-)-efonidipine and studied its effect on the progression of this type of renal injury in spontaneously hypertensive rats that had undergone subtotal nephrectomy. Treatment with racemic efonidipine for 7 weeks significantly reduced systolic blood pressure and proteinuria. The R(-)-enantiomer, however, had no effect on blood pressure but significantly reduced proteinuria compared to vehicle-treated rats. Both agents blunted the increase in tubulointerstitial fibrosis, renal expression of alpha-smooth muscle actin and vimentin along with transforming growth factor-beta (TGF-beta)-induced renal Rho-kinase activity seen in the control group. Subtotal nephrectomy enhanced renal T-type calcium channel alpha1G subunit expression mimicked in angiotensin II-stimulated mesangial cells or TGF-beta-stimulated proximal tubular cells. Our study shows that T-type calcium channel blockade has renal protective actions that depend not only on hemodyna...Continue Reading

References

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KimuraT Sugimoto
Aug 1, 1996·Journal of Biochemistry·S Narumiya
May 30, 1998·Clinical and Experimental Hypertension : CHE·K FujiwaraT Saruta
Oct 4, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·M HayashiT Saruta
Oct 14, 2000·Annual Review of Cell and Developmental Biology·W A Catterall
Oct 26, 2001·Journal of Hypertension·M HondaT Saruta
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C BaylisK Engels
Jun 26, 2002·Kidney International·Maria P RastaldiGiuseppe D'Amico
Aug 7, 2003·Journal of Vascular Research·Akira NakamuraTakao Saruta
Aug 26, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jean BarietyPatrick Bruneval
Sep 13, 2003·Kidney International. Supplement·Laura G Sánchez-LozadaJaime Herrera-Acosta
Nov 15, 2003·Circulation Research·Laurent FerronJean-François Renaud
Feb 12, 2004·Kidney International·Krissanapong ManothamMasaomi Nangaku
Mar 3, 2004·Drug News & Perspectives·Toshiki Moriyama, Katsuyuki Nagatoya
Aug 18, 2004·Journal of Hypertension·Toshio NishikimiHiroaki Matsuoka
Nov 17, 2004·British Journal of Pharmacology·Taiji FurukawaToshihide Nukada
Dec 16, 2004·Journal of Pharmacological Sciences·Hikaru TanakaKoki Shigenobu
Jan 4, 2005·American Journal of Nephrology·Ming-Guo Feng, L Gabriel Navar
May 20, 2005·Journal of the American Society of Nephrology : JASN·Sharmila PatelZhi Zhang
Jun 7, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Caiqiong LiuLuke J Janssen
Dec 13, 2005·Kidney International. Supplement·Mónica RupérezMarta Ruiz-Ortega
Jun 23, 2006·Journal of the American Society of Nephrology : JASN·Guang-Ping SunAkira Nishiyama
Feb 20, 2007·Circulation Research·Koichi HayashiTakao Saruta
May 30, 2007·Seminars in Nephrology·Erwin P Böttinger

❮ Previous
Next ❯

Citations

Sep 17, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koichi HayashiUNKNOWN JATOS Study Group
Jun 10, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masanori AbeMasayoshi Soma
Dec 21, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H TokuyamaH Itoh
Mar 8, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Naoki WashidaHiroshi Itoh
Jul 14, 2014·Cardiovascular Research·Marc ChevalierJean-François Quignard
Oct 1, 2010·The Keio Journal of Medicine·Koichi HayashiHiroshi Itoh
Feb 5, 2016·Journal of Pharmaceutical and Biomedical Analysis·Man LiuHuichen Liu
Oct 22, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ayumi YoshifujiHiroshi Itoh
Mar 15, 2008·Kidney International·P Hart, G L Bakris
Sep 5, 2015·Nature Reviews. Drug Discovery·Carmel B NanthakumarSimon J F Macdonald
Jun 12, 2013·The American Journal of Pathology·Andrea Cove-SmithBruce M Hendry
Oct 5, 2016·Expert Opinion on Investigational Drugs·J Tamargo, Luis Miguel Ruilope
Oct 27, 2017·American Journal of Physiology. Renal Physiology·Eui-Jung ParkTae-Hwan Kwon
May 30, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi KidoguchiTakashi Yokoo
Dec 19, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pernille B L Hansen
Nov 9, 2021·Clinical and Experimental Nephrology·Shoko OhnoHideki Yokoi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.