T-type calcium channels in neuropathic pain

Pain
Emmanuel BourinetSophie Laffray

Abstract

Pain is a quite frequent complaint accompanying numerous pathologies. Among these pathological cases, numerous neuropathies are retrieved with identified etiologies (chemotherapies, diabetes, surgeries…) and also more diffuse syndromes such as fibromyalgia. More broadly, pain is one of the first consequences of most inherited diseases. Despite its importance for the quality of life, current pain management is limited to drugs that are either old or with a limited efficacy or that possess a bad risk benefit ratio. As no new pharmacological concept has led to new analgesics in the last decades, the discovery of new medications is needed, and to this aim, the identification of new druggable targets in pain transmission is a first step. Therefore, studies of ion channels in pain pathways are extremely active. This is particularly true with ion channels in peripheral sensory neurons in dorsal root ganglia known how to express unique sets of these channels. Moreover, both spinal and supraspinal levels are clearly important in pain modulation. Among these ion channels, we and others revealed the important role of low voltage-gated calcium channels in cellular excitability in different steps of the pain pathways. These channels, by bei...Continue Reading

References

Apr 1, 1985·Pflügers Archiv : European journal of physiology·J L BossuJ M Thomann
Feb 1, 1985·The Journal of Physiology·S A FedulovaN S Veselovsky
Jan 1, 1983·Journal of Neurophysiology·H AdriaensenJ Van Hees
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F Crick
Oct 29, 1993·Science·M SteriadeT J Sejnowski
Jun 11, 1998·Neuroscience·E G Jones
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·R R LlinásP P Mitra
Jul 30, 2002·Nature Neuroscience·H OlaussonM C Bushnell
Dec 31, 2002·Physiological Reviews·Edward Perez-Reyes
Jun 17, 2003·Nature Neuroscience·Jung-Bum ShinGary R Lewin
Nov 25, 2003·Science·Chien-Chang ChenKevin P Campbell
Jan 20, 2004·The Journal of Biological Chemistry·Houman KhosravaniGerald W Zamponi
Oct 1, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne-Sophie DubreuilFrédérique Scamps
Dec 18, 2004·Bioorganic & Medicinal Chemistry Letters·Hyewhon RhimJae Yeol Lee
Sep 27, 2005·Brain : a Journal of Neurology·Johannes SarntheinDaniel Jeanmonod
Jun 7, 2006·The Journal of Biological Chemistry·Igor SplawskiMark T Keating
Jul 4, 2006·Physiological Reviews·Houman Khosravani, Gerald W Zamponi
Aug 31, 2006·Genes, Brain, and Behavior·S ChoiH-S Shin
Oct 19, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi OkayamaYoshihiko Saito
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yiru ShenTuck Wah Soong
Dec 8, 2006·Bioorganic & Medicinal Chemistry·Jung Hwan ParkEun Joo Roh

❮ Previous
Next ❯

Citations

May 28, 2016·Molecular Brain·Yung-Hui Kuan, Bai-Chuang Shyu
Oct 22, 2016·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Sheng-Jie ShiueJen-Kun Cheng
Jan 23, 2017·Biochimica Et Biophysica Acta. Biomembranes·Joanna Lazniewska, Norbert Weiss
Apr 4, 2017·Acta Physiologica·R González-Ramírez, R Felix
Oct 30, 2018·Expert Opinion on Therapeutic Patents·Ghilsoo Nam
Oct 30, 2018·Pain·Andrey V BortsovInna Belfer
Nov 6, 2018·Molecular Diversity·Sara RanjbarRamin Miri
Jun 2, 2020·Journal of Neuroscience Research·Shiyi Wang, Constanza J Cortes
Oct 3, 2018·Current Medicinal Chemistry·Dan WangRichard J Lewis
Jan 24, 2020·Frontiers in Molecular Neuroscience·Elizabeth Martínez-HernándezErika S Piedras-Rentería
Jul 25, 2019·International Journal of Molecular Sciences·Arturo AndradeLaura Londrigan
Jul 2, 2020·Pflügers Archiv : European journal of physiology·Cornelia AblingerGerald J Obermair
Oct 5, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Xianjie WenShijie Li
Sep 23, 2018·Breast Cancer Research and Treatment·Anamika Bhargava, Sumit Saha
May 12, 2019·Neurosurgery·Robert Y NorthPatrick M Dougherty
Jul 9, 2020·Pflügers Archiv : European journal of physiology·Philippe LoryArnaud Monteil
Sep 19, 2017·Molecular Neurobiology·Damien P Kuffler
Jan 19, 2018·Cancer Research·Marta C SallánCarles Cantí
Oct 16, 2020·Molecular Pain·Jia-Yi LiaoZeng-Xu Liu
Mar 13, 2021·Progress in Neurobiology·Rabia Bouali-BenazzouzPascal Fossat
Nov 27, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nicolas KerckhoveChristophe Mallet
Jun 28, 2019·Chemical Reviews·Emelie FloodToby W Allen
Aug 19, 2021·Physiological Reports·Michael BietRobert Dumaine

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